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Table 3 Quantitative gene (mRNA) expression data in ventricular samples from a background of no cardiac disease (Control), idiopathic cardiomyopathy (IDC) and ischemic cardiomyopathy (ICM).

From: ACE2 gene expression is up-regulated in the human failing heart

Target

Copy number with 95% CI

 

Control

(n = 9)

IDC

(n = 11)

Δ from

Control

ICM

(n = 12)

Δ from Control

ACE2

3,978

(2,102–5,531)

9,612†

(5,873–15,734)

2.4

7,338†

(5,304–10,153)

1.8

ACE

720

(349–1,484)

2,239†

(1,343–3,735)

3.1

1,692†

(1,295–2,211)

2.4

ANF

19,547

(4,377–87,287)

248,243†

(57,940–10,635,486)

12.7

151,551

(57,743–397,759)

7.8

AT 1

623

(456–850)

594

(347–1,020)

0.95

541

(352–829)

0.87

RENIN

0

0

 

0

 
  1. Values are geometric mean copy number for each gene/100 ng total RNA. † – P < 0.05 disease group Vs. Control.
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BMC Medicine

ISSN: 1741-7015

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