Neoadjuvant or adjuvant therapy for resectable esophageal cancer: a systematic review and meta-analysis

Table 1 Studies included in this systematic review.

Treatment Approach	Number of Trials	Reference Numbers	Summary of Results
Randomized Controlled Trials
Preoperative RT v. Surgery Alone	6	5*,21–25†	Table 2
Postoperative RT v. Surgery Alone	4	5*,27–29,47	Table 3
Preoperative RT v. Postoperative RT	1	5*	-
Preoperative RT + Postoperative RT v. Postoperative RT	1	30	-
Preoperative CT v. Surgery Alone	6	24†,32–35^‡,37,48	Table 4
Preoperative + Postoperative CT v. Surgery Alone	2	31,36	Table 5
Postoperative CT v. Surgery Alone	3	39–41^‡	Table 6
Preoperative CRT v. Surgery Alone	6	24†,42–46,51–53^‡	Table 7
Postoperative CT v. Postoperative RT	1	56	-
Preoperative CT v. Preoperative RT	2	24†,57	-
Preoperative CRT v. Preoperative RT	1	58	-
Postoperative Immunotherapy with RT or CRT v. RT or CRT	1	59	-
Preoperative Hyperthermia with CRT v. preoperative CRT	1	60	-
Meta-analyses
Preoperative RT v. Surgery Alone	1	26	-
Preoperative CT v. Surgery Alone	2	38,49,50	-
Preoperative CRT v. Surgery Alone	2	54^‡,55	-

Note: CT indicates chemotherapy; CRT, chemoradiation; RT, radiotherapy; v., versus.
* The four-arm trial by Fok et al [5] contributed to three comparisons.
† The four-arm trial by Nygaard et al [24] contributed to four comparisons.
‡ Reports published in abstract form only [35,41,51,53,54].

ISSN: 1741-7015