Your privacy, your choice

We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media.

By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection.

See our privacy policy for more information on the use of your personal data.

for further information and to change your choices.
Skip to main content

Table 1 Summary of aging-related diseases affected by caloric restriction in experimental animal models and clinical trialsa

From: Epigenetic regulation of caloric restriction in aging

Diseases

Findings

Rodents

Nonhuman primates

Humans

References

Cancer

CR prevents a broad range of cancer incidences, including breast and gastrointestinal cancer.

Y

Y

Y/?

[17, 13, 23]

Diabetes

CR improves glucose homeostasis and prevents diabetes.

Y

Y

Y

[18, 13, 23, 24]

Cardiovascular diseases

CR lowers blood pressure and favorably alters lipid profile, resulting in significantly reducing the risk of cardiovascular disease and related complications.

Y

Y

Y

[19, 13, 22–24]

Neurodegenerative diseases

CR reduces aging-associated neuronal loss and neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease.

Y

Y

Y/?

[20, 13, 23]

Immune deficiencies

CR delays the onset of T-lymphocyte-dependent autoimmune diseases.

Y

Y/?

Y/?

[21]

  1. aCR, caloric restriction; Y, CR has effects on relevant physiological changes; Y/?, not resolved or not reported.
Back to article page

BMC Medicine

ISSN: 1741-7015

Contact us