Fig. 1
From: Mesenchymal stem/stromal cells as a delivery platform in cell and gene therapies
MSC paracrine action/mechanisms in heart regeneration. Soluble factors released by MSC play an essential role in the post-ischemic reparative process improving angiogenesis, cytoprotection, and endogenous cardiac regeneration and reducing fibrosis. Ang-1 angiopoietin 1, HGF hepatocyte growth factor, MSC mesenchymal stem/stromal cells, VEGF vascular endothelial growth factor