Table 1 Distribution and accuracy of individual predictors for diagnosing SCD in primary care as observed in 810 Dutch patients with lower abdominal complaints referred for endoscopy in the CEDAR study^a

 Male sex

45.1

48.2 (40.1–56.4)

18.6 (15.0–22.9)

55.6 (51.8–59.3)

83.6 (79.9–86.7)

–

0.0

 Age in years, median (min–max)

61 (19–92)

–

–

–

–

0.602 (0.553–0.652)

0.0

 Absence of abdominal pain

19.3

33.0 (25.7–41.1)

29.7 (23.1–37.3)

83.5 (80.5–86.1)

85.5 (82.6–88.0)

–

0.4

 Duration of abdominal pain in weeks, median (min–max)

90 (0–10 years)^d

–

–

–

–

0.597 (0.543–0.652)^e

7.4

 Rectal blood loss

43.6

66.0 (57.8–73.3)

26.3 (22.0–31.1)

61.1 (57.3–64.7)

89.5 (86.3–92.0)

–

0.6

 Rectal mucus

38.0

51.3 (43.1–59.5)

23.5 (19.1–28.6)

64.9 (61.2–68.4)

86.3 (83.1–89.1)

–

1.2

 Weight loss

19.2

23.8 (17.4–31.5)

21.6 (15.8–28.7)

81.8 (78.7–84.6)

83.6 (80.5–86.2)

–

0.7

 Change in bowel habit

65.5

68.0 (58.6–76.4)

18.1 (14.9–21.7)

35.1 (31.4–38.9)

83.9 (78.8–88.1)

–

12.3

 Absence of abdominal bloating

45.0

60.5 (52.1–68.4)

23.4 (19.3–28.1)

58.3 (54.5–62.1)

87.5 (84.1–90.3)

–

4.2

 Absence of fever

89.0

89.2 (83.0–93.4)

17.4 (14.8–20.4)

11.0 (8.9–13.6)

82.9 (73.7–89.4)

–

0.6

 Absence of constipation

42.1

50.0 (41.8–58.2)

20.7 (16.7–25.3)

59.6 (55.7–63.3)

85.0 (81.4–87.9)

–

3.5

 Diarrhoea

29.1

29.4 (22.4–37.4)

17.6 (13.2–23.0)

71.0 (67.4–74.3)

82.7 (79.3–85.5)

–

1.6

 Absence of family history of CRC

81.7

84.3 (76.0–90.6)

17.9 (15.1–21.1)

18.8 (15.7–22.3)

85.0 (77.6–90.7)

–

14.2

 Absence of palpable abdominal mass

95.2

95.6 (89.5–99.3)

17.5 (14.9–20.4)

4.9 (3.4–6.9)

84.4 (67.3–95.3)

–

14.8

 Abnormal digital rectal examination

7.8

11.5 (6.6–18.5)

25.7 (14.5–39.7)

92.9 (89.8–95.5)

83.3 (80.4–85.8)

–

17.7

Blood analyses

 Hb in g/dL, mean (SD)

14.2 (1.3)

–

–

–

–

0.556 (0.502–0.610)^f

4.4

 Anaemia (♀ < 12 and ♂ < 13 g/dL)

5.5

9.9 (5.8–16.0)

31.0 (18.9–46.1)

95.4 (93.4–96.8)

83.4 (80.6–85.9)

–

4.4

 CRP in mg/L, median (min–max)

2 (0–20)^d

–

–

–

–

0.587 (0.535–0.638)

4.6

 Elevated CRP (≥10 mg/L)

9.4

12.2 (7.5–18.9)

22.7 (14.5–33.5)

91.2 (88.8–93.2)

83.1 (80.2–85.7)

–

4.6

 Calprotectin POC test in μg/g, median (min–max)

48 (30–300)

–

–

–

–

0.681 (0.629–0.732)

5.6

 Positive calprotectin POC test (>50 μg/g^g)

48.7

69.6 (61.4–76.7)

24.9 (20.8–29.4)

55.7 (51.8–59.5)

89.7 (86.4–92.3)

–

5.6

 Calprotectin ELISA test in μg/g, median (min–max)

62 (8–500)^d

–

–

–

–

0.661 (0.606–0.716)

8.6

 Positive calprotectin ELISA test (>50 μg/g^g)

56.6

71.4 (63.2–78.5)

21.9 (18.4–26.0)

46.5 (42.6–50.4)

88.5 (84.7–91.5)

–

8.6

 Positive POC FIT (>6 μg Hb/g^h)

25.1

67.2 (58.9–74.5)

46.5 (39.6–53.7)

83.7 (80.5–86.6)

92.4 (89.9–94.3)

–

6.2