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Table 2 Hazard ratios (95% confidence intervals) for colorectal cancer risk according to plant-based diet indices in the Multiethnic Cohort Study, 1993–2017

From: Plant-based dietary patterns defined by a priori indices and colorectal cancer risk by sex and race/ethnicity: the Multiethnic Cohort Study

 

Men (n = 79,952)

Women (n = 93,475)

P for heterogeneity by sex

No. of cases

HR (95% CI)a

No. of cases

HR (95% CI)a

Overall plant-based diet index

 Q1 (23–43)

487

1.00 (ref)

385

1.00 (ref)

 

 Q2 (44–47)

583

0.89 (0.79–1.01)

556

0.98 (0.86–1.12)

 

 Q3 (48–50)

579

0.95 (0.84–1.07)

535

0.99 (0.86–1.13)

 

 Q4 (51–53)

475

0.89 (0.78–1.01)

424

0.88 (0.77–1.02)

 

 Q5 (54–71)

458

0.76 (0.67–0.87)

494

0.99 (0.86–1.14)

 

 P for trend

 

 < 0.001

 

0.53

0.05

Healthful plant-based diet index

 Q1 (27–43)

518

1.00 (ref)

455

1.00 (ref)

 

 Q2 (44–47)

614

0.95 (0.84–1.06)

533

0.97 (0.85–1.10)

 

 Q3 (48–50)

532

0.96 (0.85–1.08)

486

1.06 (0.93–1.20)

 

 Q4 (51–54)

500

0.85 (0.75–0.96)

475

0.93 (0.81–1.06)

 

 Q5 (55–75)

418

0.79 (0.69–0.91)

445

0.91 (0.80–1.04)

 

 P for trend

 

0.0001

 

0.14

0.047

Unhealthful plant-based diet index

 Q1 (23–43)

497

1.00 (ref)

472

1.00 (ref)

 

 Q2 (44–47)

594

0.93 (0.83–1.05)

568

0.96 (0.85–1.09)

 

 Q3 (48–50)

512

0.97 (0.86–1.10)

477

0.96 (0.85–1.09)

 

 Q4 (51–53)

424

0.96 (0.84–1.09)

398

0.97 (0.85–1.11)

 

 Q5 (54–74)

555

1.08 (0.95–1.22)

479

1.01 (0.89–1.15)

 

 P for trend

 

0.19

 

0.85

0.24

  1. aModels were adjusted for age at cohort entry, race and ethnicity, family history of colorectal cancer, history of colorectal polyp, body mass index, pack-years of cigarette smoking, multivitamin use, nonsteroidal anti-inflammatory drug use, physical activity, menopausal hormone therapy use for women only, alcohol consumption, and total energy intake