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Fig. 2 | BMC Medicine

Fig. 2

From: METTL3 facilitates kidney injury through promoting IRF4-mediated plasma cell infiltration via an m6A-dependent manner in systemic lupus erythematosus

Fig. 2

Upregulation of IRF4 was related to kidney damage in SLE patients. A Schematic diagram of MeRIP-seq detecting the m6A level of IRF4; B qRT-PCR for IRF4 mRNA expression in PBMCs of healthy controls (HC), SLE-AP, and SLE-SP; C Western blotting for IRF4 protein expression in PBMCs of HC, SLE-AP and SLE-SP; Correlation between IRF4 expression and the proportions of peripheral T lymphocytes (D), T helper cells (E), suppressor T cells (F), NK cells (G) and B lymphocytes (H) in SLE patients (n=12); I Correlation between IRF4 expression and the proportions of peripheral B lymphocytes in SLE-AP (n=5). *P<0.05, **P<0.01, ***P<0.001

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BMC Medicine

ISSN: 1741-7015

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