Neurobehavioral disorders among children born to mothers exposed to illicit substances during pregnancy

Table 4 Competing risk adjusted Cox regression analysis of intellectual disability, autistic disorder, and attention deficit and hyperactivity disorder (propensity score matched, total n = 8312)

Variable	Espoused period	Unadjusted analysis		Adjusted analysis model 1		Adjusted analysis model 2
Variable	Espoused period	Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value
ADHD	Unexposed	1.00		1.00		1.00
	During pregnancy	1.78 (1.44–2.22)	< 0.001	1.80 (1.45–2.24)	< 0.001	1.77 (1.42–2.21)	< 0.001
	Before pregnancy	1.42 (1.13–1.79)	0.002	1.45 (1.16–1.82)	0.001	1.43 (1.14–1.80)	0.002
Intellectual disability	Unexposed	1.00		1.00		1.00
	During pregnancy	1.41 (1.01–1.95)	0.041	1.41 (1.01–1.96)	0.042	1.35 (0.97–1.88)	0.077
	Before pregnancy	0.81 (0.55–1.19)	0.274	0.82 (0.56–1.2)	0.298	0.79 (0.54–1.16)	0.233
Autistic disorder	Unexposed	1.00		1.00		1.00
	During pregnancy	0.93 (0.46–1.90)	0.851	0.93 (0.46–1.89)	0.834	0.88 (0.42–1.83)	0.733
	Before pregnancy	1.06 (0.54–2.07)	0.869	1.05 (0.54–2.06)	0.881	1.05 (0.53–2.05)	0.893

Unexposed and exposed groups distinguished by time were propensity score matched by covariates included child’s gender, child’s birth year, the year of child’s first use of health insurance card, birth orders, birth place, mother’s age at giving birth, mother’s urbanization levels, mother’s education level, mother’s marital status, Charlson comorbidity index, mothers’ levels of income, mother’s days of hospitalization, outpatient visits, medication prescribed during pregnancy, and the method of delivery (cesarean or natural birth)
Adjusted analysis model 1: without regression controlling of fifth minute APGAR score, premature birth, and low birth weight
Adjusted analysis model 2: regression controlling of fifth minute APGAR score, premature birth, and low birth weight
ADHD attention deficit and hyperactivity disorder

ISSN: 1741-7015