Table 2 Summary of identified clusters derived from LCA in people with MLTC
From: Multimorbidity clusters and their associations with health-related quality of life in two UK cohorts
Cluster Label | Leading LTCs (within-cluster prevalence [%]) | N (%) a | No. of LTCs b, median (IQR) | Female (%) | Most deprived c (%) | Mortality d, n (%) | Predicted probability of cluster membership, mean (SD) |
|---|---|---|---|---|---|---|---|
18–36 years | |||||||
UKHLS (n = 16,105) | |||||||
No multimorbidity | 15,416 (95.7) | 0 (0, 0) | 54.9 | 29.6 | |||
Pulmonary | Asthma (100%), Hypertension (33%), Arthritis (23%), COPD (14%) | 270 (1.7) | 2 (2, 2) | 65.2 | 30.0 | 0.95 (0.07) | |
Cardiometabolic | Depression (59%), Hypertension (55%), Diabetes (23%), Arthritis (21%) | 251 (1.6) | 2 (2, 2) | 69.7 | 35.5 | 0.99 (0.07) | |
Depression & Asthma | Depression (100%), Asthma (100%) | 168 (1.0) | 2 (2, 3) | 73.8 | 38.7 | 0.85 (0.13) | |
37–54 years | |||||||
UK BIOBANK (n = 194,109) | |||||||
No multimorbidity | 151,975 (78.3) | 0 (0, 1) | 54.6 | 16.7 | 2170 (1.4) | ||
Hypertension & Diabetes | Hypertension (100%), Diabetes (22%), Painful conditions (22%) | 16,126 (8.3) | 2 (2, 3) | 47.1 | 25.4 | 728 (4.5) | 0.82 (0.16) |
Asthma + | Asthma (100%), Painful conditions (24%), Psoriasis or eczema (19%) | 9680 (5.0) | 2 (2,3) | 63.8 | 21.4 | 247 (2.5) | 0.90 (0.16) |
Thyroid & Cancer | Thyroid disease (24%), Dyspepsia (24%), Cancer (22%) | 6006 (3.1) | 2 (2, 2) | 70.0 | 21.3 | 270 (4.5) | 0.99 (0.05 |
Depression & Anxiety | Depression (100%), Painful conditions (25%), Anxiety (19%) | 5250 (2.7) | 2 (2, 3) | 70.5 | 27.1 | 173 (3.3) | 0.82 (0.15) |
Pain + | Painful conditions (100%), Dyspepsia (21%), Hypertension (17%) | 5072 (2.6) | 2 (2, 3) | 64.2 | 22.0 | 131 (2.6) | 0.97 (0.11) |
UKHLS (n = 16,726) | |||||||
No multimorbidity | 14,542 (86.9) | 0 (0, 1) | 53.4 | 21.2 | |||
Pulmonary | Asthma (100%), Depression (36%), Hypertension (35%), COPD (18%) | 805 (4.8) | 2 (2, 3) | 68.7 | 30.1 | 0.99 (0.03) | |
Depression, Thyroid & Cancer | Hypertension (62%), Depression (58%), Thyroid disease (25%), Cancer (20%) | 485 (2.9) | 2 (2, 2) | 65.0 | 25.0 | 0.99 (0.03) | |
Arthritis + | Arthritis (100%), Hypertension (50%), Depression (38%) | 466 (2.8) | 2 (2, 3) | 67.2 | 32.8 | 0.99 (0.04) | |
Cardiovascular | CHD (100%), Hypertension (57%), Arthritis (38%), Asthma (26%), Diabetes (21%), Stroke (11%) | 218 (1.3) | 3 (2, 4) | 45.0 | 42.2 | 0.92 (0.11) | |
Hypertension & Diabetes | Hypertension (100%), Diabetes (100%) | 210 (1.3) | 2 (2, 3) | 51.9 | 44.8 | 0.81 (0.16) | |
55–73 years | |||||||
UK BIOBANK (n = 308,254) | |||||||
No multimorbidity | 185,265 (60.1) | 1 (0, 1) | 53.3 | 11.5 | 9095 (4.9) | ||
Cardiometabolic | Hypertension (100%), Painful conditions (33%), Diabetes (28%), CHD (23%), Stroke (8%) | 52,740 (17.1) | 2 (2, 3) | 41.7 | 18.6 | 5827 (11.1) | 0.81 (0.14) |
Pain + | Painful conditions (51%), Hypertension (34%), Dyspepsia (29%) | 33,165 (10.8) | 2 (2, 3) | 66.0 | 15.4 | 2181 (6.6) | 0.81 (0.14) |
Pulmonary | Asthma (100%), Hypertension (36%), Painful conditions (29%), COPD (12%) | 20,624 (6.7) | 2 (2, 3) | 60.7 | 15.5 | 1562 (7.6) | 0.68 (0.15) |
Cancer + | Cancer (100%), Hypertension (44%), Painful conditions (27%) | 16,460 (5.3) | 2 (2, 3) | 62.3 | 13.8 | 2115 (12.9) | 0.79 (0.12) |
UKHLS (n = 12,308) | |||||||
No multimorbidity | 8191 (66.6) | 0 (0, 1) | 51.5 | 15.4 | |||
Hypertension + | Hypertension (100%), Arthritis (54%), Diabetes (31%) | 2162 (17.6) | 2 (2, 3) | 55.4 | 22.0 | 0.88 (0.15) | |
Pulmonary | Asthma (100%), Arthritis (58%), Hypertension (34%), COPD (32%) | 730 (5.9) | 2 (2, 2) | 65.5 | 20.8 | 0.81 (0.21) | |
Depression, Thyroid & Cancer | Arthritis (78%), Depression (30%), Thyroid disease (28%), Cancer (27%) | 641 (5.2) | 3 (2, 4) | 68.0 | 17.6 | 0.94 (0.07) | |
Cardiovascular | CHD (82%), Hypertension (52%), Arthritis (48%), Diabetes (33%), Stroke (19%) | 584 (4.7) | 3 (2, 4) | 38.7 | 30.3 | 0.77 (0.16) | |
74 + years | |||||||
UKHLS (n = 4047) | |||||||
No multimorbidity | 2161 (53.4) | 1 (0, 1) | 52.3 | 15.8 | |||
Arthritis + | Arthritis (100%), Hypertension (70%), CHD (31%) | 959 (23.7) | 3 (2, 3) | 66.0 | 18.4 | 1.00 (0.00) | |
Cardiometabolic | Hypertension (78%), CHD (49%), Diabetes (40%) Stroke (22%) | 547 (13.5) | 2 (2, 3) | 42.1 | 19.7 | 1.00 (0.00) | |
Pulmonary | Asthma (100%), Arthritis (59%), Hypertension (55%), CHD (29%), COPD (24%) | 380 (9.4) | 3 (2, 4) | 61.1 | 22.4 | 1.00 (0.00) | |