Fig. 3
Meta-analysis of proportion of cell cycle markers between MI and Sham group in identified studies. A Proportion of Ki67+. B Proportion of PH3+. C Proportion of BrdU/EdU+. D Proportion of AurkB+. Study-specific mean differences (MD) are represented by squares (with their 95% confidence intervals [CIs] as lines). The size of the solid square reflects the weight of each eligible study, which represents the influence of each study on the overall effect. The overall effects are plotted as diamonds, and its intersection with an invalid line (X = 0) is considered statistically insignificant. Random effects models were used if I 2 > 50% and p < 0.05 in the heterogeneity test. Results showed no significant increase in cardiomyocyte cell cycle activation in the MI heart versus the Sham heart