Fig. 5
Meta-analysis of the proportion of cell cycle markers between infarct border and remote zone in identified studies. A Proportion of Ki67+. B Proportion of PH3+. C Proportion of BrdU/EdU+. D Proportion of AurkB+. Study-specific mean differences (MD) are represented by squares (with their 95% confidence intervals [CIs] as lines). The size of the solid square reflects the weight of each eligible study, which represents each study’s influence on the overall effect. The overall effects are plotted as diamonds, and its intersection with an invalid line (X = 0) is considered statistically insignificant. Random effects models were used if I2 > 50% and p < 0.05 in the heterogeneity test. Results showed an increase of Ki67+ cycling cardiomyocytes in the infarct border zone versus the remote zone in the same post-MI heart