Table 1 Characteristics of the identified studies on cardiomyocyte proliferation between the MI and Sham groups
Study | Years | Country | Sham (n) | MI (n) | Strains | Age | Time-points for outcome measures | Outcome measures |
|---|---|---|---|---|---|---|---|---|
Ahmad F et al. [16] | 2014 | USA | 4 | 6 | Gsk3αfl/fl | 8w | 21d post-MI | PH3 |
Avolio E et al. [17] | 2015 | UK | 3 | 6 | SCID Beige | 8w | 14d post-MI | Ki67; BrdU/EdU |
Cai B et al. [18] | 2020 | China | 4 | 3 | C57BL/6 | 8w | 14d post-MI | PH3; Aurora B |
Gao X et al. [19] | 2022 | China | 3 | 3 | Kun Ming | 8w | 14d post-MI | Ki67; PH3 |
Gong R et al. [20] | 2021 | China | 3 | 3 | C57BL/6 | 5-6w | 28d post-MI | Ki67; PH3; Aurora B |
Hu Z et al. [21] | 2022 | China | 5 | 5 | C57BL/6 | 8w | 14d post-MI | Ki67; BrdU/EdU; Aurora B |
Li Y et al. [22] | 2022 | China | 4 | 4 | ICR | 8w | 7d post-MI | BrdU/EdU |
Magadum A et al. [23] | 2017 | Germany | 4 | 4 | TMCM | 8w | 14d post-MI | BrdU/EdU |
Roy R et al. [24] | 2019 | USA | 5 | 5 | C57BL/6 J | 8w | 14d post-MI | PH3; BrdU/EdU |
Ruchaya PJ et al. [25] | 2022 | UK | 5 | 5 | C57BL/6 | 8w | 42d post-MI | BrdU/EdU |
Xie Y et al. [26] | 2014 | USA | 6 | 7 | SCID-beige | 8w | 7d post-MI | Ki67;PH3 |
Yan W et al. [27] | 2020 | China | 6 | 6 | C57BL/6 J | 8w | 3d post-MI | Ki67; BrdU/EdU |
Yang D et al. [28] | 2017 | China | 4 | 4 | C57BL/6 J | 8w | 28d post-MI | BrdU/EdU |
Yifa O et al. [29] | 2019 | Israel | 3 | 5 | C57BL/6 J | 12w | 4d post-MI | Ki67 |
Zhang Y et al. [30] | 2019 | USA | 3 | 3 | C57Bl/6 | Adults | 24d post-MI | BrdU/EdU |