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Fig. 3 | BMC Medicine

Fig. 3

From: Promising new drugs and therapeutic approaches for treatment of ovarian cancer—targeting the hallmarks of cancer

Fig. 3

Evading growth suppressors. Cell cycle progression is strictly regulated by checkpoints controlled by cyclin-dependent kinases (CDKs)/cyclin-complexes. Due to frequent aberrations in checkpoint control, as well as alterations in critical gatekeepers, uncontrolled cell cycle progression is a common feature in OC. Current strategies in phase III studies targeting evasion of growth suppressors are listed in the table. This figure was created using Biorender.com [85, 98]

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BMC Medicine

ISSN: 1741-7015

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