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Fig. 6 | BMC Medicine

Fig. 6

From: Promising new drugs and therapeutic approaches for treatment of ovarian cancer—targeting the hallmarks of cancer

Fig. 6

Genome instability and mutation. High quality repair of DNA damage is crucial to maintain genomic stability. In case of DNA damage repair defects, as homologous repair deficiency or artificially induced defects by PARP inhibition, DNA damage leads to genomic instability or cell death due to synthetic lethality. Recently completed and currently ongoing phase III trials targeting genome instability of OC are listed in the table. SSB, single-strand breaks; DSB, double-strand breaks. This figure was created using Biorender.com [72, 138, 166,167,168,169,170,171,172,173,174,175,176,177,178,179,180]

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BMC Medicine

ISSN: 1741-7015

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