Fig. 9

Further hallmarks to target. Other promising targets for treatment are the reprogramming of glucose metabolism in cancer cells and the cellular senescence of cancer by stimulating the senescence-associated secretory phenotype, which consists of proinflammatory cytokines, chemokines and matrix-reforming factors. MCT4, monocarboxylate transporter 4; ATP, adenosine triphosphate; GLUT, glucose transporter; TCA, tricarboxylic acid cycle; PDH, pyruvate dehydrogenase; HIF, hypoxia-inducible factor; ROS, reactive oxygen species; SASP, senescence-associated secretory phenotype; SA-β-gal, senescence-associated beta-galactosidase. This figure was created using Biorender.com