Fig. 1

Multivariable-adjusted associations of combined Sleep, Physical Activity, and Nutrition with all-cause mortality risk. Legend: Model is adjusted for age, sex, ethnicity, smoking, education, Townsend deprivation index, alcohol, discretionary screen time (time spent watching TV or using the computer outside of work), light intensity physical activity, medication (blood pressure, insulin, and cholesterol), previous diagnosis of major CVD (defined as disease of the circulatory system, arteries, and lymph, excluding hypertension), previous diagnosis of cancer, and familial history of CVD and cancer (n = 59,078; events = 2,458). Sleep (hours/day), physical activity (moderate to vigorous intensity (MVPA) minutes/day), and nutrition (Dietary Quality Score (DQS)) were included in the model as a joint term. The specific ranges for each exposure included sleep duration as 4.8-7.2 hours/day (low), 7·2-8.0 hours/day (medium), and 8.0-9.4 hours/day (high); MVPA measurements as 5-23 minutes/day (low), 23-42 minutes/day (medium), and 42-103 minutes/day (high); and diet quality using the DQS as 32.5-50.0 (low), 50.0-57.5 (medium), and 57.5-72.5 (high). The lowest tertiles for all three exposures (sleep, MVPA and DQS) was considered the reference group. Dashed blue lines separate tertiles MVPA and dashed black lines separate tertiles of sleep. Sleep (Slp); Low Diet Quality (LD); Medium Diet Quality (MD); High Diet Quality (HD)