Table 1 Participant characteristics

Sample

59,078

19,693

19,692

19,693

19,693

19,692

19,693

20,918

19,464

18,696

Events, n

2,458

980

698

780

1,276

693

489

856

783

819

Follow up, years (median [IQR])

8.06 [7.49, 8.59]

8.05 [7.48, 8.56]

8.07 [7.51, 8.59]

8.05 [7.51, 8.59]

8.05 [7.46, 8.59]

8.06 [7.52, 8.59]

8.07 [7.52, 8.56]

8.06 [7.50, 8.59]

8.06 [7.50, 8.59]

8.05 [7.49, 8.56]

Age, years (median [IQR])

64.00 [57.00, 69.00]

64.00 [57.00, 69.00]

63.00 [56.00, 68.00]

64.00 [57.00, 69.00]

66.00 [60.00, 70.00]

64.00 [57.00, 69.00]

62.00 [55.00, 67.00]

62.00 [55.00, 68.00]

64.00 [57.00, 69.00]

65.00 [59.00, 70.00]

Male, n (%)

26,810 (45.4%)

10,068 (51.1%)

10,822 (55.0%)

11,378 (57.8%)

8,445 (42.9%)

9,002 (45.7%)

9,363 (47.5%)

10,582 (50.6%)

8,115 (41.7%)

8,113 (43.4%)

Sleep, hours/day (median [IQR])

7.62 [6.89, 8.26]

6.52 [5.92, 6.89]

7.62 [7.41, 7.83]

8.52 [8.26, 8.89]

7.60 [6.78, 8.30]

7.65 [6.92, 8.27]

7.62 [6.94, 8.22]

7.61 [6.86, 8.26]

7.62 [6.90, 8.25]

7.64 [6.90, 8.27]

Moderate to vigorous physical activity, mins/day (median [IQR])

31.26 [18.52, 49.09]

30.17 [17.52, 48.19]

33.05 [19.79, 51.31]

30.60 [18.24, 47.79]

14.31 [9.64, 18.52]

31.26 [26.76, 36.26]

58.74 [49.09, 74.91]

30.57 [18.24, 48.31]

31.67 [18.76, 49.43]

31.60 [18.59, 49.64]

Diet quality score (median [IQR])

54.29 [47.50, 60.00]

53.93 [47.50, 60.00]

54.01 [47.50, 60.00]

54.64 [47.50, 60.00]

53.93 [47.50, 60.00]

54.29 [47.50, 60.00]

54.29 [47.50, 60.00]

45.00 [40.00, 47.50]

55.00 [52.50, 56.79]

62.50 [60.00, 67.50]

Light physical activity, mins/day (median [IQR])

102.84 [70.24, 158.12]

106.72 [72.26, 162.46]

105.17 [72.00, 162.25]

96.81 [66.72, 149.53]

83.96 [59.79, 118.6]

107.43 [73.38, 157.72]

130.86 [81.72, 195.7]

100.81 [69.03, 155.55]

103.91 [71.26, 158.90]

103.98 [70.53, 159.82]

Discretionary screen time, hours/day (median [IQR])

3.50 [2.50, 5.00]

4.00 [2.50, 5.00]

3.50 [2.50, 5.00]

3.50 [2.50, 5.00]

4.00 [3.00, 5.00]

3.50 [2.50, 5.00]

3.00 [2.00, 4.50]

4.00 [2.50, 5.00]

3.50 [2.50, 5.00]

3.50 [2.50, 5.00]

Smoking history, n (%)

-

-

-

-

-

-

-

-

-

-

 Never

34,024 (57.6%)

10,910 (554%)

11,508 (58.4%)

11,606 (58.9%)

10,781 (54.7%)

11,462 (58.2%)

11,781 (59.8%)

11,928 (57.0%)

11,385 (58.5%)

10,711 (57.3%)

 Former

21,361 (36.2%)

7,320 (37.2%)

7,026 (35.7%)

7,015 (35.6%)

7,390 (37.5%)

7,076 (35.9%)

6,895 (35.0%)

7,236 (34.6%)

7,039 (36.2%)

7,086 (37.9%)

 Current

3,693 (6.3%)

1,463 (7.4%)

1,158 (5.9%)

1,072 (5.4%)

1,522 (7.7%)

1,154 (5.9%)

1,017 (5.2%)

1,754 (8.4%)

1,040 (5.3%)

899 (4.8%)

Alcohol consumption, units/week^b (median [IQR])

9.75 [1.70, 19.50]

9·52 [0.97, 19.50]

9.75 [2.44, 19.50]

9.75 [2.27, 19.57]

8·77 [0.62, 18.84]

9.75 [2.27, 19.50]

10.71 [3.20, 20.52]

9.75 [1.22, 20.13]

9.75 [2.44, 19.50]

9.75 [1.94, 19.50]

Total energy intake, kcal/day (median [IQR])^a

2,018 [1,651, 2,443]

2,056 [1,676, 2,500]

2,026 [1,662, 2,441]

1,975 [1,617, 2,392]

1,965 [1,607, 2,382]

2,011 [1,649, 2,435]

2,075 [1,699, 2,511]

2,045 [1,677, 2,490]

2,017 [1,652, 2,433]

1,989 [1,620, 2,413]

Townsend Deprivation Index, (median [IQR]])

−2.49 [−3.84, −0.26]

−2.33 [−3.76, 0.13]

−2.50 [−3.83, −0.34]

−2.64 [−3.91, −0.59]

−2.41 [−3.78, −0.12]

−2.54 [−3.88, −0.34]

−2.52 [−3.85, −0.31]

−2.44 [−3.81, −0.09]

−2.52 [−3.87, −0.40]

−2.52 [−3.84, −0.33]

Education, n (%)

-

-

-

-

-

-

-

-

-

-

 College/University

7,707 (13.0%)

2,615 (13.3%)

2,533 (12.9%)

2,559 (13.0%)

2,523 (12.8%)

2,605 (13.2%)

2,579 (13.1%)

2,740 (13.1%)

2,636 (13.5%)

2,331 (12.5%)

 A/AS

25,619 (43.4%)

8,642 (43.9%)

8,882 (45.1%)

8,095 (41.1%)

8,095 (41.1%)

8,725 (44.3%)

8,799 (44.7%)

8,574 (41.0%)

8,780 (45.1%)

8,265 (44.2%)

 O levels

3,262 (5.5%)

1,090 (5.5%)

1,065 (5.4%)

1,107 (5.6%)

1,145 (5.8%)

1,097 (5.6%)

1,020 (5.2%)

1,264 (6.0%)

989 (5.1%)

1,009 (5.4%)

 CSE

12,028 (20.4%)

3,897 (19.8%)

3,923 (19.9%)

4,208 (21.4%)

4,104 (20.8%)

3,982 (20.2%)

3,942 (20.0%)

4,422 (21.1%)

3,896 (20.0%)

3,710 (19.8%)

 NVQ/HND/HNC

2,216 (3.8%)

716 (3.6%)

714 (3.6%)

786 (4.0%)

642 (3.3%)

685 (3.5%)

889 (4.5%)

943 (4.5%)

669 (3.4%)

604 (3.2%)

 Other

8,246 (14.0%)

2,733 (13.9%)

2,575 (13.1%)

2,938 (14.9%)

3,184 (16.2%)

2,598 (13.2%)

2,464 (12.5%)

2,975 (14.2%)

2,494 (12.8%)

2,777 (14.9%)

Parental history of CVD, n (%)

33,120 (56.1%)

11,074 (56.2%)

10,976 (55.7%)

11,070 (56.2%)

11,510 (58.4%)

11,004 (55.9%)

10,606 (53.9%)

11,144 (53.3%)

11,050 (56.8%)

10,926 (58.4%)

Parental history of cancer, n (%)

18,549 (31.4%)

6,177 (314%)

6,150 (31.2%)

6,222 (31.6%)

6,162 (31.3%)

6,252 (31.7%)

6,135 (31.2%)

6,509 (31.1%)

6,167 (31.7%)

5,873 (31.4%)

Previous CVD, n (%)

5,678 (9.6%)

2,132 (10.8%)

1,754 (8.9%)

1,792 (9.1%)

2,668 (13.5%)

1,732 (8.8%)

1,278 (6.5%)

1,971 (9.4%)

1,796 (9.2%)

1,911 (10.2%)

Previous Cancer, n (%)

5,145 (8.7%)

1,676 (8.5%)

1,672 (8.5%)

1,797 (9.1%)

2,036 (10.3%)

1,715 (8.7%)

1,394 (7.1%)

1,709 (8.2%)

1,737 (8.9%)

1,699 (9.1%)

Ethnicity, n (%)

-

-

-

-

-

-

-

-

-

-

 Other

3,565 (6.0%)

1,552 (7.9%)

1,115 (5.7%)

898 (4.6%)

1,160 (5.9%)

1,162 (5.9%)

1,243 (6.3%)

1,257 (6.0%)

1,186 (6.1%)

1,122 (6.0%)

 White

55,513 (94.0%)

18,141 (92.1%)

18,577 (94.3%)

18,795 (95.4%)

18,533 (94.1%)

18,530 (94.1%)

18,450 (93.7%)

19,661 (94.0%)

18,278 (93.9%)

17,574 (94.0%)

Medication Use, n (%)

-

-

-

-

-

-

-

-

-

-

 Cholesterol

9,130 (15.5%)

3,426 (17.4%)

2,756 (14.0%)

2,948 (15.0%)

4,200 (21.3%)

2,870 (14.6%)

2,060 (10.5%)

2,835 (13.6%)

2,855 (14.7%)

3,440 (18.4%)

 Blood pressure

5,384 (9.1%)

1,997 (10.1%)

1,680 (8.5%)

1,707 (8.7%)

2,287 (11.6%)

1,723 (8.7%)

1,374 (7.0%)

1,782 (8.5%)

1,749 (9.0%)

1,853 (9.9%)

 Insulin

72 (0.1%)

21 (0.1%)

29 (0.1%)

22 (0.1%)

22 (0.1%)

27 (0.1%)

23 (0.1%)

23 (0.1%)

18 (0.1%)

31 (0.2%)

Frailty Index > 3, n (%)

196 (0.3%)

95 (0.5%)

51 (0.3%)

50 (0.3%)

142 (0.8%)

24 (0.1%)

30 (0.2%)

91 (0.5%)

53 (0.3%)

52 (0.3%)

Self-rated health, n (%)

-

-

-

-

-

-

-

-

-

-

 Excellent

12,827 (21.8%)

3,930 (20.0%)

4,534 (23.1%)

4,363 (22.2%)

3,148 (16.0%)

4,382 (22.3%)

5,297 (26.9%)

4,138 (19.8%)

4,322 (22.2%)

4,367 (23.4%)

 Good

35,514 (60.2%)

11,533 (58.7%)

11,970 (60.9%)

12,011 (61.1%)

11,583 (58.9%)

12,099 (61.5%)

11,832 (60.2%)

12,421 (59.5%)

11,897 (61.2%)

11,196 (60.0%)

 Fair

9,175 (15.6%)

3,563 (18.1%)

2,774 (14.1%)

2,838 (14.4%)

4,083 (20.8%)

2,803 (14.3%)

2,289 (11.6%)

3,654 (17.5%)

2,814 (14.5%)

2,707 (14.5%)

 Poor

1,458 (2.5%)

634 (3.2%)

378 (1.9%)

446 (2.3%)

844 (4.3%)

374 (1.9%)

240 (1.2%)

660 (3.2%)

394 (2.0%)

404 (2.2%)

Body mass index, kg/m² (median [IQR])

26.10 [23.60, 29.00]

26.70 [24.10, 29.90]

25.80 [23.50, 28.70]

25.70 [23.30, 28.50]

27.20 [24.50, 30.50]

26.00 [23.60, 28.80]

25.20 [23.00, 27.70]

26.40 [23.90, 29.40]

26.00 [23.60, 28.90]

25.80 [23.40, 28.70]