Table 2 Pathology and radiology variables

Follow-up time

 10-year overall survival follow-up period median follow-up time (KM-PF)^a, median ± SE^a, years

5.1 ± 0.8

3.9 ± 0.6

0.24

 1-year progression-free survival period median follow-up time (KM-PF), median ± SE*, months

11.5 ± 1.7

12 ± 1.7

0.78

Pathology

 Fine needle aspiration (FNA), n (%)

82 (93)

53 (80)

0.02

Cell type, n (%)

 < 0.001

 Adenocarcinoma

42 (48)

51 (76)

 Adenosquamous

2 (2)

1 (1)

 Squamous

38 (43)

10 (15)

 Large cell

0 (0)

1 (1)

 Poorly differentiated

6 (7)

4 (6)

 Surgical excision, n (%)

25 (28)

32 (48)

0.01

Cell type on surgical path, n/N (%)

0.22

 Adenocarcinoma

14/25 (56)

23/32 (72)

 Adenosquamous

1/25 (4)

0/32 (0)

 Squamous

10/25 (40)

8/32 (25)

 Large cell

0/25 (0)

0/32 (0)

 Poorly differentiated

0/25 (0)

1/32 (3)

Subtype (if applicable), n/N (%)

0.21

 Acinar

8/15 (53)

6/24 (25)

 Papillary

0/15 (0)

4/24 (17)

 Bronchoalveolar

0/15 (0)

3/24 (12)

 Poorly differentiated

4/15 (27)

7/24 (7)

 Other

0/15 (0)

1/24 (1)

 Acinar and papillary

2/15 (13)

2/24 (8)

 Acinar and papillary and bronchoalveolar

0/15 (0)

1/24 (4)

 Acinar and large cell

1/15 (0)

0/24 (0)

 Size of tumor, mean ± SD, cm³

30 ± 83

30 ± 59

0.98

 Greatest dimension, mean ± SD, mm

28 ± 15

29 ± 21

0.87

Tumor genotype, n (%)

 < 0.001

 No genotyping

32 (37)

18 (29)

 EGFR

6 (7)

20 (32)

 ALK

1 (1)

6 (10)

 MET

1 (1)

0 (0)

 BRAF

1 (1)

3 (5)

 RAS

8 (9)

1 (2)

 HER2

1 (1)

2 (3)

 Other

33 (38)

9 (15)

 EGFR and other

0 (0)

1 (2)

 EGFR and ALK

0 (0)

2 (3)

 EGFR and RAS

1 (1)

0 (0)

 HER2 and other

1 (1)

0 (0)

 ROSI and other

1 (1)

0 (0)

Lymphovascular invasion, n (%)

9/25 (36)

9/27 (33)

0.84

Pleural invasion, n (%)

12/25 (48)

9/27 (33)

0.28

Radiology

Location of nodule, n (%)

0.11

 RLL

22 (25)

24 (36)

 RML

3 (3)

8 (12)

 RUL

30 (34)

16 (24)

 LLL

9 (10)

9 (13)

 Lingula

2 (2)

1 (1)

 LUL

22 (25)

9 (13)

Nodule size in 2 dimensions, mean ± SD, cm²

17 ± 26

16 ± 21

0.81

 Missing data

(n = 3)

Greatest dimension, mean ± SD, mm

40 ± 27

41 ± 26

0.88

 Missing data

(n = 3)

General nodule morphology, n (%)

0.47

 Solid

81 (92)

56 (88)

 Part solid

7 (8)

7 (11)

 Nonsolid or ground glass

0 (0)

1 (2)

 Missing data

(n = 3)

Suspicious morphology (if applicable), n (%)

0.050

 None

3 (3)

1 (2)

 Spiculated

23 (26)

16 (27)

 Lobulated margin

28 (32)

14 (24)

 Cystic/cavitary components

8 (9)

5 (8)

 Part solid

3 (3)

2 (3)

 Spiculated and lobulated margin

7 (8)

18 (31)

 Spiculated and cystic/cavitary components

4 (5)

0 (0)

 Spiculated and part solid

2 (2)

1 (2)

 Lobulated margin and cystic/cavitary component

3 (3)

0 (0)

 Spiculated and lobulated margin and cys/cav comp

5 (6)

2 (3)

 Lobulated margin and cys/cav comp and part solid

1 (1)

0 (0)

Missing data

(n = 3)

 Nodule calcifications, n (%)

4 (5)

3 (5)

 > 0.99

Missing data

(n = 3)

 Nodule invades adjacent structures on CT, n (%)

66 (75)

48 (75)

 > 0.99

Missing data

(n = 3)

 Single or multiple nodules, n (%)

0.75

 Single nodule

38 (43)

26 (41)

 Multiple nodules > 4 mm

50 (57)

38 (59)

 Missing data

(n = 3)

Total nodules, n (%)

0.67

 Single nodule

38 (43)

26 (41)

< 10 nodules > 4 mm

36 (41)

26 (41)

 10 or more nodules > 4 mm

14 (16)

12 (19)

 Missing data

(n = 3)

Underlying lung disease on staging CT, n (%)

 <0.001

 Absent

36 (41)

61 (95)

 Emphysema

50 (57)

1 (2)

 Interstitial lung disease

2 (2)

2 (3)

 Missing data

(n = 3)

Enlarged mediastinal or hilar LNs at staging, n (%)

45 (51)

37 (58)

0.41

 Missing data

(n = 3)

Extrathoracic metastases on staging imaging, n (%)

24 (27)

27 (42)

0.055

 Missing data

(n = 3)

Metastases location at staging, n (%)^b

 None

32 (36)

20 (31)

0.51

 Lung

33 (38)

36 (56)

0.02

 Mediastinal/ipsilateral hilar LN

44 (50)

34 (53)

0.70

 Contralateral LN

14 (16)

10 (16)

0.96

 Distant LNs

11 (12)

16 (25)

0.047

 Pleura/pericardium

15 (17)

13 (20)

0.61

 Bone

9 (10)

12 (19)

0.13

 Liver

3 (3)

3 (5)

0.70

 Brain

8 (9)

8 (12)

0.50

 Adrenal

8 (9)

4 (6)

0.52

 Other

5 (6)

4 (6)

0.88

 Missing data

(n = 3)

Primary nodule FDG avid on PET (if applicable), n (%)

0.59

 Yes

78 (90)

55 (86)

 No

0 (0)

1 (2)

 No PET

9 (10)

8 (12)

 Missing data

(n = 3)