Fig. 4
From: Genetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis
Potential plasma protein mechanisms by which BRSK2 promotes IPF. A Sankey diagram of plasma protein-mediated pathways for BRSK2 to promote the development of IPF. B Colocalization analysis of Cis-pQTL for PSMB1 (deCODE) and GWAS for IPF (FinnGen). C Colocalization analysis of BRSK2 promoting IPF mediation protein and IPF. D KEGG enrichment analysis of blood BRSK2 (eQTLGen) affecting plasma protein content. E KEGG enrichment analysis of lung BRSK2 (GTEX) affecting plasma protein content. IPF, idiopathic pulmonary fibrosis; GWAS, genome-wide association study; eQTL, expression quantitative trait loci; pQTL, protein quantitative trait loci; PPH, posterior probabilities for hypotheses; KEGG, Kyoto Encyclopedia of Genes and Genomes