Table 2 SMR analysis results for BRSK2 and IPF complication and prognosis
From: Genetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis
Exposure (BRSK2) | Outcome | TopSNP | OR | Lower OR Ci95 | Upper OR Ci95 | Pval | Nsnp | Pval (HEIDI) |
|---|---|---|---|---|---|---|---|---|
GTEX-Lung | ILD-related respiratory insufficiency | rs7395567 | 1.437 | 0.998 | 2.070 | 5.131E − 02 | 8 | 2.478E − 03 |
GTEX-Lung | Transplant-free survival | rs4255564 | 0.782 | 0.518 | 1.179 | 2.409E − 01 | 7 | 1.462E − 01 |
UKBPPP-Blood | ILD-related respiratory insufficiency | rs7395567 | 1.191 | 1.006 | 1.411 | 4.200E − 02 | 20 | 8.124E − 11 |
UKBPPP-Blood | Transplant-free survival | rs7932863 | 0.859 | 0.709 | 1.042 | 1.233E − 01 | 20 | 1.028E − 02 |
deCODE-Blood | ILD-related respiratory insufficiency | rs4881748 | 3.879 | 2.058 | 7.311 | 2.754E − 05 | 20 | 6.552E − 05 |
deCODE-Blood | Transplant-free survival | rs4881748 | 0.481 | 0.240 | 0.964 | 3.909E − 02 | 20 | 4.104E − 02 |
eQTLGen-Blood | ILD-related respiratory insufficiency | rs11603658 | 5.802 | 1.118 | 30.105 | 3.634E − 02 | 20 | 7.281E − 02 |
eQTLGen-Blood | Transplant-free survival | rs11603658 | 0.249 | 0.047 | 1.317 | 1.018E − 01 | 20 | 7.445E − 02 |