Table 2 Associations of antidepressants with cognitive decline by antidepressant class and individual drugs
From: Antidepressant use and cognitive decline in patients with dementia: a national cohort study
Antidepressant class | β (95%CIs) | P |
|---|---|---|
Non-use | Ref | Â |
 SSRIs |  − 0.39 (− 0.50, − 0.28) |  < .001 |
 SNRIs | 0.24 (− 0.29, 0.77) | 0.381 |
 TCAs | 0.16 (− 0.36, 0.68) | 0.543 |
 Others |  − 0.20 (− 0.35, − 0.05) | 0.011 |
Non-use | Ref | Â |
 Citalopram (SSRI) |  − 0.41 (− 0.55, − 0.27) |  < .001 |
 Sertraline (SSRI) |  − 0.25 (− 0.43, − 0.06) | 0.011 |
 Escitalopram (SSRI) |  − 0.76 (− 1.09, − 0.44) |  < .001 |
 Venlafaxine (SNRI) | 0.09 (− 0.56, 0.74) | 0.791 |
 Amitriptyline (TCA) | 0.16 (− 0.36, 0.68) | 0.543 |
 Mirtazapine (Other) |  − 0.19 (− 0.34, − 0.04) | 0.014 |
SSRIs | Ref | Â |
 SNRIs | 0.43 (− 0.10, 0.96) | 0.114 |
 TCAsa | 0.29 (− 0.27, 0.85) | 0.316 |
 Others | 0.18 (0.01, 0.34) | 0.035 |
Sertraline (SSRI) | Ref | Â |
 Citalopram (SSRI) | 0.28 (0.17, 0.39) |  < .001 |
 Escitalopram (SSRI) |  − 0.51 (− 0.89, − 0.12) | 0.01 |
 Venlafaxine (SNRI) | 0.14 (− 0.49, 0.77) | 0.665 |
 Amitriptyline (TCA)a |  − 0.01 (− 0.69, 0.68) | 0.986 |
 Mirtazapine (Other) | 0.08 (− 0.16, 0.31) | 0.509 |