Fig. 1

Schematic diagram of serum SERS multi-cancer detection architecture. A Type of cancers enrolled in this study. B Serum collection and silver colloid preparation. C SERS spectrum acquisition. D Mean SERS spectra for each category of serum. E Resampling of the training set samples. F Deep neural network model. G Spectral data dimensionalization. H Convolutional neural network model. I Model evaluation. J Interpretability analysis of the convolutional neural network