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Fig. 5 | BMC Medicine

Fig. 5

From: Immune microenvironment spatial landscapes of tertiary lymphoid structures in gastric cancer

Fig. 5

The enhanced interaction of tumour cells in the TLS-deficient microenvironment is largely related to immunosuppression. A UMAP plots showed the two annotated clusters including malignant cells and non-malignant ECs. B, C Depiction of interaction probabilities with tumour cells as signal transmitters and other cell types as signal receivers mediated by ligand–receptor pairs in TLS+ (B) and TLS− (C) group. D, E Comparison of the overall information flow of each signal pathway with tumour cell as signal transmitters between TLS+ (D) and TLS− (E) group. F, G Spatial feature plots of signature score of B cells (F), and T cells (G) in P1. H Gene ontology (GO) analysis showing enriched biological process terms of differentially expressed genes (DEGs) in TLS than tumour in P1. TLS, tertiary lymphoid structure; UMAP, Uniform Manifold Approximate and Projection

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BMC Medicine

ISSN: 1741-7015

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