Virtual biopsy for non-invasive identification of follicular lymphoma histologic transformation using radiomics-based imaging biomarker from PET/CT

Table 1 Characteristics of the study population

Characteristic	Training and internal validation cohort		t-FL test cohort		P value^*
Characteristic	FnL (n = 379)	DLBCL (n = 300)	FL (n = 80)	t-FL (n = 25)	P value^*
Gender
Male	171	167	36	12	0.822
Female	208	133	44	13	0.822
Age (years)
Median^#	55	51	49	57	0.019
Q1–Q3	45–67	42–59	41–58	48–68	0.019
Elevate LDH
No	307	185	71	17	0.026
Yes	72	115	9	8	0.026
ECOG PS
0–1	356	271	59	12	0.026
≥ 2	23	29	21	13	0.026
Ann arbor staging
I–II	81	143	17	3	0.391
III–IV	298	157	63	22	0.391
B symptoms
No	317	223	61	22	0.268
Yes	62	77	19	3	0.268
Hemoglobin < 120 g/L
No	292	-	56	16	0.625
Yes	87	-	24	9	0.625
Elevate Serum β2-MG
No	189	-	42	9	0.174
Yes	190	-	38	16	0.174

Abbreviations: DLBCL diffuse large B-cell lymphoma, FL follicular lymphoma, t-FL transformed follicular lymphoma, LDH lactate dehydrogenase, ECOG PS Eastern Cooperative Oncology Group performance status, LDH lactate dehydrogenase, β2-MG β2-microglobulin
^＃Median (range)
^＊P value derived from the Mann–Whitney U test or χ² test in t-FL test cohort
A P-value of < 0.05 indicates statistical significance

ISSN: 1741-7015