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Table 3 The ovarian reserve and controlled ovarian hyperstimulation of HBsAg positive e antigen-negative group, HBsAg positive e antigen-positive group and HBsAg negative group

From: Positive hepatitis B surface antigen leads to a decrease in ovarian reserve in infertile patients receiving first in vitro fertilization treatment

 

HBsAg+ HBeAg(n = 1356)

HBsAg+ HBeAg+(n = 218)

HBsAg HBeAg(n = 1574)

P

No. of AFC

11 (7, 16)b

12 (8, 16)b

18 (14, 20)a

< 0.001

FSH (IU/L)

7.9 (6.49, 9.5)a

7.73 (6.5, 9.44)a

6.82 (5.81, 8.1)b

< 0.001

LH/FSH

0.49 (0.36, 0.68)b

0.52 (0.39, 0.72)b

0.63 (0.48, 0.85)a

< 0.001

AMH (ng/ml)

2.2 (1.17, 3.57)b

2.56 (1.31, 4.18)b

6.81 (5.56, 8.24)a

< 0.001

Duration of GN stimulation (days)

10 (9,12)

10 (9, 11.25)

10 (9, 11)

0.187

Total dose of GN used (IU)

1912.5 (1431.25, 2350)a

1800 (1425, 2250)ab

1600 (1300, 2100) b

< 0.001

No. of oocytes retrieved

7 (4, 12)b

9 (4, 13)b

14 (10, 18)a

< 0.001

No. of MII eggs

6 (3, 11)b

8 (4, 11)b

12 (8, 16)a

< 0.001

  1. AFC antral follicle count, FSH follicle-stimulating hormone, LH luteinizing hormone, AMH anti-mullerian hormone, Gn gonadotropins, MII mature
  2. Different letters (ab) on the same line indicate statistically significant differences between groups, with a P value < 0.05