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Table 1 Control and treatment group delivery data. There were no statistically significant differences in birthweight, cord pH or cord pCO2 between steroid treatment groups (CS1, CS2) and saline negative control animals. There was a small, statistically significant (p < 0.001) reduction in wet lung weight between CS1 and saline negative control animals. As anticipated, there were large, statistically significant (p < 0.001) perturbations in circulating fetal neutrophil and lymphocyte counts between steroid treatment groups (CS1, CS2) and saline negative control animals

From: Single-nucleotide polymorphisms in dizygotic twin ovine fetuses are associated with discordant responses to antenatal steroid therapy

Treatment group

CS1

CS2

Negative control

Sub-group

Total

Responders

Non-responders

Total

Responders

Non-responders

Total

n

22

12

10

20

12

8

20

Sex (male/female)

13/9

7/5

6/4

9/11

3/9

6/2

8/12

Gestation age (days)

125

125

125

125

125

125

125

Birthweight (kg)

2.97 ± 0.34

3.15 ± 0.27

2.76 ± 0.29

2.84 ± 0.42

2.86 ± 0.37

2.81 ± 0.52

2.71 ± 0.38

Cord blood pH

7.28 ± 0.11

7.25 ± 0.13

7.32 ± 0.05

7.29 ± 0.14

7.32 ± 0.12

7.26 ± 0.18

7.22 ± 0.10

Cord blood PaCO2 (mmHg)

60.68 ± 13.59

63.44 ± 16.11

56.99 ± 8.84

59.05 ± 16.10

57.36 ± 11.03

61.38 ± 21.96

66.15 ± 11.14

Lung weight (g/kg)

30.95 ± 5.22*

30.15 ± 5.15*

31.90 ± 5.42*

34.24 ± 4.93

33.24 ± 4.38

35.73 ± 5.62

38.47 ± 5.51

Cord blood values

Total WBC (× 109/L)

4.4 ± 1.15

4.48 ± 0.81

4.39 ± 1.51

3.57 ± 0.65

3.39 ± 0.60

3.90 ± 0.66

4.17 ± 1.29

Neutrophils (× 109/L)

2.53 ± 1.16*

2.52 ± 0.93*

2.54 ± 1.44*

1.91 ± 0.70*

1.63 ± 0.65*

2.41 ± 0.52*

0.34 ± 0.27

Lymphocytes (× 109/L)

1.65 ± 0.60*

1.68 ± 0.62*

1.63 ± 0.61*

1.60 ± 0.65*

1.69 ± 0.73*

1.43 ± 0.47*

3.48 ± 1.04

  1. Values are expressed as mean ± one standard deviation
  2. *p < 0.001 vs negative control group