Single-nucleotide polymorphisms in dizygotic twin ovine fetuses are associated with discordant responses to antenatal steroid therapy

Table 4 Fetal single-nucleotide polymorphism (SNPs) statistically associated with ANS responsiveness

SNP	Gene	Chromosome	Position	Effect	Reference allele	Responder allele	p-value Cut-off ChiSQ p-value < 0.01 LR p-value < 0.05	Non-responder allele	p-value Cut-off ChiSQ p-value < 0.01 LR p-value < 0.05
OAR15_69180648.1	APIP	15	63,627,667	Intron variant	C	Allele1 – Forward C***	0.001 0.0009	Allele2 – Forward C*	0.008 0.030
oar3_OAR7_34804896	CAPN3	7	34,804,896	3′ UTR variant	C	Allele2 – Forward C***	0.0003 < 0.0001	Allele1 – Forward C*	0.006 0.029
oar3_OAR1_87387610	CD53	1	87,387,610	Intron variant	A	Allele2 – Forward A***	0.001 < 0.0001	Allele1 – Forward A*	0.008 0.038
OAR2_251639875.1	EYA3	2	238,259,883	Intron variant	A	Allele1 – Forward A**	0.003 0.006	-
oar3_OAR3_133208610	IGFBP6	3	133,208,610	Downstream gene variant	T	-		Allele1 – Forward C*	0.006 0.034
oar3_OAR1_40819378	LEPR	1	40,819,378	Intron variant	A	Allele1 – Forward A**	0.007 0.008	Allele1 – Forward G***	0.0002 < 0.0001
oar3_OAR4_51540896	MET	4	51,540,896	Intron variant	A	Allele2 – Forward A*	0.005 0.019	-
s64770.1	MET	4	51,565,726	Intron variant	C	Allele1 – Forward C*	0.005 0.019	-
OAR5_56257273.1	NR3C1	5	51,843,084	Intron variant	T	Allele2 – Forward C*	0.009 0.021	Allele1 – Forward C***	0.001 < 0.0001
oar3_OAR6_97080753	SCD5	6	97,080,753	Intron variant	T	Allele1 – Forward C*	0.005 0.016	-
zoar3_OARX_51195419	SHROOM4	X	51,195,419	Intron variant	T	Allele2 – Forward C***	0.0006 0.0008	Allele1 – Forward C**	0.009 0.007
oar3_OAR2_192174047	STAT1	2	192,174,047	Intron variant	T	Allele1 – Forward C*	0.002 0.019	-

ISSN: 1741-7015