Your privacy, your choice

We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media.

By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection.

See our privacy policy for more information on the use of your personal data.

for further information and to change your choices.
Skip to main content
Fig. 5 | BMC Medicine

Fig. 5

From: Helicobacter pylori SlyD stabilizes TPT1 via hnRNPK and enhances OCT1-mediated CDX2 transcriptional activation to drive gastric intestinal metaplasia

Fig. 5

OCT1 binds to the CDX2 promoter and directly regulates its transcription. A Prediction of the binding sites of OCT1 to the promoter region of CDX2 by JASPAR database. B Potential binding sites and CDX2-promoter mutant constructs. C Dual-luciferase reporter assay to determine the relative luciferase activity of the CDX2 promoter (including wild-type and mutants). The luciferase assay was repeated for three times. D ChIP-qPCR to validate the binding of OCT1 to the CDX2 promoter region. The assay was repeated twice and represented as mean ± SD. Agarose gel electrophoresis showed the representative bands of two independent ChIP experiments. Significance Levels: *P < .05, **P < .01, ***P < .001, ns: non-significant

Back to article page

BMC Medicine

ISSN: 1741-7015

Contact us