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Table 3 Multivariable analysis investigating the association between systemic nutrition/inflammation risk and postoperative endpoints in the development cohort (n = 1497)

From: Development and validation of the systemic nutrition/inflammation index for improving perioperative management of non-small cell lung cancer

Endpoints

SNII risk

Univariable analysis

Multivariable analysis [OR/HR (95% CI)]

OR/HR (95% CI)

P value

Model 1

P value

Model 2

P value

Model 3

P value

Overall complicationsa

High

2.57 (1.70–3.88)

 < 0.001

1.64 (1.05–2.56)

0.031

1.67 (1.04–2.67)

0.034

1.68 (1.05–2.70)

0.031

Moderate

1.86 (1.21–2.86)

0.005

1.54 (0.97–2.40)

0.058

1.58 (0.99–2.52)

0.057

1.56 (0.98–2.50)

0.062

Low (reference)

–

–

–

–

–

–

–

–

Major complications (Clavien–Dindo grades ≥ 2)a

High

2.54 (1.57–4.13)

 < 0.001

1.75 (1.05–2.91)

0.032

1.75 (1.04–2.93)

0.035

1.83 (1.07–3.15)

0.028

Moderate

1.83 (1.10–3.05)

0.019

1.61 (0.96–2.70)

0.069

1.57 (0.93–2.66)

0.091

1.64 (0.95–2.83)

0.075

Low (reference)

–

–

–

–

–

–

–

–

Chest tube durationb

High

0.719 (0.611–0.846)

 < 0.001

0.769 (0.642–0.922)

0.004

0.819 (0.685–0.979)

0.029

0.802 (0.675–0.952)

0.012

Moderate

0.782 (0.665–0.919)

0.003

0.829 (0.698–0.985)

0.033

0.859 (0.723–1.020)

0.083

0.855 (0.722–1.012)

0.068

Low (reference)

–

–

–

–

–

–

–

–

Length of postoperative hospital stayb

High

0.708 (0.625–0.802)

 < 0.001

0.821 (0.718–0.939)

0.004

0.823 (0.713–0.949)

0.007

0.823 (0.713–0.949)

0.008

Moderate

0.826 (0.729–0.936)

0.003

0.878 (0.773–0.997)

0.045

0.890 (0.778–1.017)

0.087

0.895 (0.783–1.024)

0.11

Low (reference)

–

–

–

–

–

–

–

–

  1. Multivariate analyses were conducted to establish the independent association between systemic nutrition/inflammation risk and postoperative endpoints, after controlling for confounding clinicopathological parameters. The models varied based on the inclusion of different clinicopathological characteristics as follows: model 1 included adjustments for demographic data (age, gender, smoking history, Charlson comorbidity index, and lung function); model 2 further incorporated adjustments for surgical data (operation time, estimated blood loss, and lymph node dissection); and model 3 encompassed adjustments for demographic and surgical data, as well as cancer characteristics (tumor location, histology, and cancer stage)
  2. SNII systemic nutrition/inflammation index
  3. aMultivariate logistic regression analyses were conducted with the backward conditional method and results are reported as odds ratios (ORs) and 95% confidence intervals (CIs)
  4. bMultivariate Cox’s proportional hazards regression analyses were conducted with the backward conditional method and results are reported as hazard ratios (HRs) and 95% CIs