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Fig. 9 | BMC Medicine

Fig. 9

From: Cryoablation-induced modulation of Treg cells and the TGF-β pathway in lung adenocarcinoma: implications for increased antitumor immunity

Fig. 9

Cryoablation modulates IFN-γ and IL-2 expression to enhance antitumor immunity. A, D Changes in serum IFN-γ and IL-2 levels before and after surgery in 17 patients. Statistical significance was evaluated using the paired t-test. *P < 0.05, **P < 0.01, ***P < 0.001. B, E Serum IFN-γ and IL-2 levels in mouse models 2 weeks post-cryoablation. n = 3 mice per group. Statistical significance was evaluated using one-way ANOVA (B) and the Brown-Forsythe and Welch ANOVA tests (E). *P < 0.05, **P < 0.01. C, F Expression levels of IFN-γ and IL-2 in the supernatant after co-culture with a cell cryoablation model and PBMCs. Statistical significance was evaluated using one-way ANOVA (C) and the Brown-Forsythe and Welch ANOVA tests (F). *P < 0.05, ** P < 0.01

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BMC Medicine

ISSN: 1741-7015

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