Table 2 HRs (95% CIs) for primary and secondary outcomes by HLFs score in ADVANCE
Number of HLFs | Per point increase in HLFs score | |||||
|---|---|---|---|---|---|---|
0 | 1 | 2 | ≥ 3 | P trend | ||
Combined macrovascular and microvascular events | ||||||
Events, n (%) | 286 (23.3) | 907 (20.4) | 716 (17.6) | 214 (15.3) | ||
Model 1 | 1.00 | 0.87 (0.76–1.00) | 0.73 (0.64–0.84) | 0.62 (0.52–0.74) | < 0.001 | 0.85 (0.81–0.89) |
Model 2 | 1.00 | 0.84 (0.74–0.97) | 0.72 (0.63–0.83) | 0.68 (0.57–0.81) | < 0.001 | 0.87 (0.83–0.92) |
Macrovascular events | ||||||
Events, n (%) | 171 (14.0) | 500 (11.3) | 369 (9.1) | 105 (7.5) | ||
Model 1 | 1.00 | 0.81 (0.68–0.97) | 0.64 (0.54–0.77) | 0.52 (0.40–0.66) | < 0.001 | 0.80 (0.75–0.86) |
Model 2 | 1.00 | 0.81 (0.68–0.97) | 0.66 (0.55–0.79) | 0.58 (0.46–0.75) | < 0.001 | 0.83 (0.78–0.89) |
Microvascular events | ||||||
Events, n (%) | 140 (11.4) | 480 (10.8) | 390 (9.6) | 121 (8.6) | ||
Model 1 | 1.00 | 0.95 (0.79–1.15) | 0.83 (0.68–1.00) | 0.73 (0.57–0.93) | 0.001 | 0.89 (0.83–0.95) |
Model 2 | 1.00 | 0.87 (0.72–1.06) | 0.77 (0.63–0.93) | 0.78 (0.61–0.99) | 0.007 | 0.91 (0.85–0.97) |
All-cause mortality | ||||||
Events, n (%) | 166 (13.5) | 463 (10.4) | 314 (7.7) | 88 (6.3) | ||
Model 1 | 1.00 | 0.76 (0.64–0.91) | 0.56 (0.46–0.67) | 0.44 (0.34–0.57) | < 0.001 | 0.75 (0.70–0.81) |
Model 2 | 1.00 | 0.76 (0.64–0.91) | 0.57 (0.47–0.69) | 0.48 (0.37–0.63) | < 0.001 | 0.77 (0.72–0.83) |