Fig. 2

The diagnostic results of participants with different assays. a Time delay in the diagnosis of tuberculosis (TB) via Mtb culture (culture), GenenXpert MTB/RIF (Xpert), TB-LAMP (LAMP), and targeted next-generation sequencing (tNGS). The time delay was defined as the time from specimen submission to the reporting of results. Two-sided p values from the Wilcoxon rank-sum test. b Results profile of the detection of 313 participants with different TB classifications via culture, Xpert, LAMP, and tNGS. c Venn diagram of tNGS and the indicated assays, including culture, Xpert, or LAMP, in participants post hoc classified as confirmed TB/EPTB (n = 96). d Distribution of tNGS-positive results for different types of specimens from participants with different TB classifications. NA indicates that the participant did not take the test or failed the test. ^a Assessed post hoc on the basis of adapted critical (Additional file 1: Table S2). ^b Seven cerebrospinal fluid samples, four blood samples, and two urine samples were included. Abbreviations: BALF bronchoalveolar lavage fluid, EPTB extrapulmonary tuberculosis, NA not amplicabale