Table 2 tNGS results in children with suspected TB and adults with suspected EPTB
|  | Confirmed TB/EPTBa (n = 96) | Unconfirmed TB/EPTBa (n = 69) | Unlikely TB/EPTBa (n = 13) | Non-TBa (n = 135) |
|---|---|---|---|---|
tNGS for all participants, N = 313 | ||||
  tNGS positivity (n/N) | 80/96 | 45/69 | 0/13 | 3/135 |
  Sensitivity, % (95% CI) | 83% (76–89%) | 65% (53–75%) | - | - |
  Specificity, % (95% CI) | - | - | 100 (77–100%) | 98% (94–99%) |
tNGS for children with suspected TB, N = 85 | ||||
  tNGS positivity (n/N) | 30/37 | 10/17 | 0/6 | 1/25 |
  Sensitivity, % (95% CI) | 81% (66–91%) | 59% (36–78%) | - | - |
  Specificity, % (95% CI) | - | - | 100% (61–100%) | 96% (80–100%) |
tNGS for adults with suspected EPTB, N = 228 | ||||
  tNGS positivity (n/N) | 50/59 | 35/52 | 0/7 | 2/110 |
  Sensitivity, % (95% CI) | 85% (73–92%) | 67% (54–78%) | - | - |
  Specificity, % (95% CI) | - | - | 100% (65–100%) | 98% (94–100%) |