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Fig. 10 | BMC Medicine

Fig. 10

From: Enhancing anti-CD3 mAb-mediated diabetes remission in autoimmune diabetes through regulation of dynamin-related protein 1(Drp1)-mediated mitochondrial dynamics in exhausted CD8+T-cell subpopulations

Fig. 10

Combining anti-CD3 mAb and OAM induces TEX cell in T1D patients. MFI variations of ATP5O, CytoC in anti-CD3 unstimulated and stimulated overnight in exhausted and non-exhausted CD8+ T cells or TPEX and TEX cells from PBMCs in T1D patients respectively. MTG, MTR, and normalized ΔΨm (MTR/MTG ratio) in TPEX and TEX cells from PBMCs in controls (A) and T1D patients (B) respectively. C Flow cytograms and analysis of total exhausted CD8+ T cells, TPEX, and TEX cells generated with O/A, Mdivi-1, or O/A/M. Analysis of IFN-γ and TNF-α generated in TPEX cells (D) and TEX (E) cells with O/A, Mdivi-1, or O/A/M in T1D patients. F Flow cytograms and analysis of total exhausted CD8+ T cells, TPEX, and TEX cells generated with anti-CD3mAb, or a combination of anti-CD3mAb and O/A/M in T1D patients. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Mann Whitney test (A,B); one-way ANOVA (C–F). Data represent two independent experiments

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BMC Medicine

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