Table 3 Relationships between gene expression and biofilm structure, HAP, VAP or CAP infection; and pneumonia status within 7 days in the patients with chronic P. aeruginosa lung infection (n = 70) based on the odds ratio (OR) as standardised (Z score) adjusted for sex and age: P < 0.05 was considered to indicate significance

OR (95% CI) P

OR (95% CI) P

OR (95% CI) P

Gene expression

tesG

3115.14 (2.31, 4203918.49) 0.025

2.48 (1.44, 4.26) 0.001

0.49 (0.29, 0.85) 0.01

lasR

36.87 (6.85, 198.42) 0.0010

2.29 (1.36, 3.89) 0.002

0.45 (0.26, 0.79) 0.004

rhlA

46.32 (7.42, 289.16) 0.0010

1.91 (1.14, 3.19) 0.014

0.58 (0.34, 0.97) 0.036

lasB

141.22 (8.23, 2424.23) 0.0010

2.14 (1.24, 3.68) 0.006

0.53 (0.30, 0.92) 0.021

lasA

9.84 (3.49, 27.82) 0.0010

1.73 (1.04, 2.89) 0.034

0.61 (0.36, 1.05) 0.069

sagS

1.54 (0.91, 2.63) 0.105

2.47 (1.39, 4.39) 0.002

0.45 (0.25, 0.81) 0.006

rsmY

2.99 (1.61, 5.58) 0.0010

7.28 (3.28, 16.16) 0

0.18 (0.08, 0.38) < 0.001

rsmZ

3.31 (1.72, 6.38) 0.0010

7.89 (3.44, 18.12) 0

0.14 (0.06, 0.34) < 0.001

pelB

1020.45 (9.29, 112044.57) 0.003

1.98 (1.16, 3.36) 0.011

0.53 (0.30, 0.92) 0.021

phzF

2,300,401.50 (0, 18394) 0.286

2.37 (1.38, 4.06) 0.001

0.51 (0.30, 0.87) 0.011

algD

29.66 (5.97, 147.27) 0.0010

2.48 (1.44, 4.26) 0.001

0.49 (0.29, 0.85) 0.01