Association of Life’s Essential 8 with incidence of heart failure modified by depressive symptoms: a prospective cohort study from UK Biobank

Table 3 Joint and interactive effects of LE8-defined CVH and depressive symptoms on the incidence of HF

CVH status	Joint effect		Additive interaction			Multiplicative interaction
	Depressive symptoms (HR, 95% CI)^a		No depressive symptoms			P for interaction^c
	Yes	No	RERI (95% CI)^b	AP (95% CI)^b	SI (95% CI)^b	P for interaction^c
Low CVH	1 (Reference)	0.731 (0.650, 0.822)				0.016
Moderate CVH	0.571 (0.504, 0.648)	0.440 (0.394, 0.491)	0.136 (0.030, 0.242)	0.308 (0.039, 0.576)	0.804 (0.699, 0.925)
High CVH	0.375 (0.263, 0.534)	0.344 (0.295, 0.401)	0.229 (0.070, 0.388)	0.658 (0.168, 1.149)	0.740 (0.619, 0.884)

Note: ^aAll results were calculated adjusted by age, sex, education, ethnicity, Townsend Deprivation Index, alcohol drinking status, total sedentary time, hypertension, diabetes, and cancer. ^bThe estimates of RERI, AP, and SI were calculated based on the reference group with depressive symptoms and low CVH; an additive interaction was indicated if neither the 95% CI for RERI nor the 95% CI for AP contained zero or the 95% CI of the SI did not contain one. ^cLikelihood tests were applied to test the significance of interaction term by comparing the model with and without the interaction term
Abbreviations: LE8, Life’s Essential 8; HF, heart failure; CVH, cardiovascular health; AP, attributable proportion due to interaction; RERI, relative excess risk due to interaction; SI, synergy index; HR, hazard ratio; CI, confidence interval

ISSN: 1741-7015