Table 1 Baseline characteristics of the study population
Characteristics | N (col%) | Person-years | N cases | Incidence/1000 person-years |
|---|---|---|---|---|
Age at recruitment (years) | ||||
< 50 | 109,518 (24.4) | 1,285,540 | 1769 | 1.4 |
≥ 50– < 60 | 151,929 (33.8) | 1,740.891 | 6822 | 3.9 |
≥ 60 | 187,489 (41.8) | 2,076,075 | 12,698 | 6.1 |
Sex | ||||
Male | 208,913 (46.5) | 2,372,402 | 6931 | 2.9 |
Female | 240,023 (53.5) | 2,726,104 | 14,358 | 5.3 |
Adulthood BMI (kg/m2)a | ||||
Normal weight | 148,227 (33.0) | 1,695,266 | 6117 | 3.6 |
Overweight | 191,167 (42.6) | 2,173,739 | 8846 | 4.1 |
Obesity | 109,542 (24.4) | 1,229,501 | 6326 | 5.1 |
Childhood body size | ||||
Thinner | 148,556 (33.3) | 1,696,304 | 10,661 | 4.1 |
Average | 227,743 (50.7) | 2,590,054 | 7191 | 4.2 |
Plumper | 71,637 (16.0) | 812,149 | 3437 | 4.2 |
Body size change | ||||
Thinner → normal weight | 59,987 (13.4) | 685,795 | 2449 | 3.6 |
Thinner → overweight | 61,767 (13.8) | 700,209 | 3026 | 4.3 |
Thinner → obesity | 27,802 (6.2) | 310,299 | 1716 | 5.5 |
Average → normal weight | 74,567 (16.6) | 853,253 | 3098 | 3.6 |
Average → overweight | 101,467 (22.6) | 1,155,456 | 4599 | 4.0 |
Average → obesity | 51,709 (11.5) | 581,344 | 2964 | 5.1 |
Plumper → normal weight | 13,673 (3.0) | 156,217 | 570 | 3.6 |
Plumper → overweight | 27,933 (6.2) | 318,073 | 1221 | 3.8 |
Plumper → obesity | 30,031 (6.7) | 337,858 | 1646 | 4.9 |
Ethnicity/race | ||||
White | 423,915 (94.7) | 4,818,012 | 20,540 | 4.3 |
Mixed-other | 6587 (1.5) | 74,056 | 239 | 3.2 |
Asian-Chinese | 9988 (2.2) | 112,094 | 302 | 2.7 |
Black | 6997 (1.6) | 78,207 | 205 | 2.6 |
Missing | 1449 | 16,137 | 64 | 4.0 |
Deprivation index (quartiles) | ||||
1 (most affluent) | 112,097 (25.0) | 1,283,045 | 5376 | 4.2 |
2 | 112,097 (25.0) | 1,275,206 | 5502 | 4.3 |
3 | 112,097 (25.0) | 1,269,356 | 5231 | 4.1 |
4 (most deprived) | 112,097 (25.0) | 1,264,632 | 5180 | 4.1 |
Missing | 549 | 6267 | 17 | 2.7 |
Qualifications | ||||
Higher academic/professional | 221,333 (49.8) | 2,528,962 | 9761 | 3.9 |
Lower academic/vocational | 149,332 (33.6) | 1,693,881 | 6805 | 4.0 |
None | 73,935 (16.6) | 827,025 | 4507 | 5.4 |
Missing | 4336 | 48,638 | 216 | 4.4 |
Smoking status | ||||
Never | 246,570 (55.1) | 2,822,337 | 10,853 | 3.8 |
Former | 153,757 (34.4) | 1,733,483 | 8160 | 4.7 |
Current | 47,089 (10.5) | 525,767 | 2214 | 4.2 |
Missing | 1520 | 16,916 | 62 | 3.7 |
Alcohol consumption | ||||
Never | 91,909 (20.5) | 1,040,275 | 4537 | 4.4 |
Special occasions only | 104,846 (23.4) | 1,199,570 | 4562 | 3.8 |
1–3 times a month | 116,158 (25.9) | 1,324,991 | 5164 | 3.9 |
Once or twice a week | 50,001 (11.1) | 569,057 | 2319 | 4.1 |
3–4 times a week | 50,699 (11.3) | 569,774 | 2822 | 5.0 |
Daily or almost daily | 34,995 (7.8) | 391,148 | 1865 | 4.8 |
Missing | 328 | 3691 | 20 | 5.4 |
Physical activity (IPAQ groups) | ||||
Low | 63,918 (18.3) | 721,525 | 3114 | 4.3 |
Moderate | 141,536 (40.6) | 1,608,584 | 6738 | 4.2 |
High | 142,993 (41.0) | 1,627,191 | 6050 | 3.7 |
Missing | 100,489 | 1,141,206 | 5387 | 4.7 |
Fruit intake (pieces/day) | ||||
< 2 | 124,208 (27.7) | 1,407,088 | 5373 | 3.8 |
≥ 2– < 5 | 236,989 (52.9) | 2,695,635 | 11,463 | 4.3 |
≥ 5 | 86,953 (19.4) | 987,091 | 4420 | 4.5 |
Missing | 786 | 8691 | 33 | 3.8 |
Vegetable intake (tablespoons/day) | ||||
< 3 | 80,409 (17.9) | 915,679 | 3488 | 3.8 |
≥ 3– < 6 | 226,427 (50.4) | 2,575,118 | 10,924 | 4.2 |
≥ 6 | 139,447 (31.1) | 1,578,107 | 6758 | 4.3 |
Missing | 2653 | 29,603 | 119 | 4.0 |
Red meat intake | ||||
Never | 30,042 (6.8) | 342,211 | 1270 | 3.7 |
Less than once a week | 151,250 (34.0) | 1,718,328 | 7558 | 4.4 |
Once a week | 96,580 (21.7) | 1,100,942 | 4553 | 4.1 |
≥ 2 times a week | 167,118 (37.5) | 1,892,858 | 7712 | 4.1 |
Missing | 3946 | 44,168 | 196 | 4.4 |
Processed meat intake | ||||
Never | 41,367 (9.2) | 471,680 | 1916 | 4.1 |
Less than once a week | 135,757 (30.3) | 1,546,012 | 6979 | 4.5 |
Once a week | 130,930 (29.2) | 1,486,012 | 6276 | 4.2 |
≥ 2 times a week | 140,036 (31.3) | 1,487,099 | 6118 | 3.9 |
Missing | 846 | 9404 | 4.3 | |
History of CRC screening | ||||
No | 306,980 (69.5) | 3,524,205 | 13,360 | 3.8 |
Yes | 134,625 (30.5) | 1,491,064 | 7640 | 5.1 |
Missing | 7331 | 83,237 | 289 | 3.5 |
History of mammography (women) | ||||
No | 51,063 (21.3) | 596,601 | 1250 | 2.1 |
Yes | 188,576 (78.7) | 2,125,072 | 13,095 | 6.2 |
Missing | 384 | 4431 | 13 | 2.9 |
Family history of breast cancer | ||||
No | 402,876 (89.7) | 4,578,914 | 18,527 | 4.0 |
Yes | 46,060 (10.3) | 519,592 | 2762 | 5.3 |
Family history of CRC | ||||
No | 400,423 (89.2) | 4,550,748 | 18,470 | 4.1 |
Yes | 48,513 (10.8) | 547,756 | 2819 | 5.1 |
Regular use of NSAIDs/aspirin | ||||
No | 311,225 (69.3) | 3,542,998 | 14,474 | 4.1 |
Yes | 137,698 (30.7) | 1,555,342 | 6815 | 4.4 |
Missing | 13 | 166 | 0 | 0 |
History of HRT use (women) | ||||
No | 149,064 (62.3) | 1,703,622 | 7575 | 4.4 |
Yes | 90,146 (37.7) | 1,013,364 | 6738 | 6.6 |
Missing | 813 | 9188 | 45 | 4.9 |