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Table 2 HRs (95% CIs) for all-cause thrombosis and venous, arterial and microvascular events according to RC level among patients with APS

From: Remnant cholesterol predicts risk of recurrent thrombosis beyond LDL-cholesterol in patients with antiphospholipid syndrome

 

RC Tertiles (mmol/L)

 
 

Tertile 1

(≤ 0.45)

Tertile 2

(> 0.45, ≤ 0.60)

Tertile 3

(> 0.60)

P-ternd

All-cause thrombosis

Number (%)

8 (7.41)

15 (13.27)

28 (26.92)

 

Model 1

HR (95% CI) P-value

1.00

1.95 (0.83, 4.60) 0.13

4.58 (2.09, 10.08) < 0.01

 < 0.001

Model 2

HR (95% CI) P-value

1.00

2.00 (0.85, 4.72)

0.11

5.13 (2.32, 11.36) < 0.01

 < 0.001

Model 3

HR (95% CI) P-value

1.00

2.10 (0.88, 4.98) 0.09

5.05 (2.23, 11.41) < 0.01

 < 0.001

Venous thrombosis

Number (%)

3 (2.78)

9 (7.96)

12 (11.54)

 

Model 1

HR (95% CI) P-value

1.00

2.99 (0.81, 11.04) 0.10

4.54 (1.28, 16.10) 0.02

0.018

Model 2

HR (95% CI) P-value

1.00

3.03 (0.82, 11.22) 0.10

4.93 (1.38, 17.60) 0.01

0.011

Model 3

HR (95% CI) P-value

1.00

3.18 (0.86, 11.85) 0.08

6.34 (1.71, 23.54) < 0.01

0.003

Arterial thrombosis

Number (%)

3 (2.78)

6 (5.31)

10 (9.62)

 

Model 1

HR (95% CI) P-value

1.00

2.04 (0.51, 8.15)

0.32

3.79 (1.04, 13.78) 0.04

0.040

Model 2

HR (95% CI) P-value

1.00

2.04 (0.51, 8.17)

0.31

3.96 (1.08, 14.48) 0.04

0.035

Model 3

HR (95% CI) P-value

1.00

1.97 (0.48, 7.98)

0.34

3.79 (1.00, 14.32) < 0.05

0.061

Microvascular disease

Number (%)

3 (2.78)

3 (2.65)

10 (9.62)

 

Model 1

HR (95% CI) P-value

1.00

1.05 (0.21, 5.20)

0.95

4.15 (1.14, 15.11) 0.03

0.029

Model 2

HR (95% CI) P-value

1.00

1.17 (0.24, 5.85)

0.85

5.47 (1.47, 20.32) 0.01

0.011

Model 3

HR (95% CI) P-value

1.00

1.47 (0.29, 7.45)

0.64

4.36 (1.08, 17.58) 0.04

0.028

  1. Model 1: Non-adjusted
  2. Model 2: Adjusted for age, sex
  3. Model 3: Adjusted for age, sex, BMI, hyperlipidemia, diabetes, smoking history, medicine use of statin, hydroxychloroquine, glucocorticoid, immunosuppressant
  4. RC Remnant cholesterol, APS Antiphospholipid syndrome, HR Hazard ratio, CI Confidence interval, BMI Body mass index