Fig. 4

Performance of the four-autoantibody signature in the preclinical esophageal squamous cell carcinoma (ESCC). a Violin plots of optical density (OD) values of autoantibodies to ALDOA, ENO1, p53, and NY-ESO- 1 from preclinical esophageal squamous cell carcinoma (ESCC) patients and matched normal controls. b Receiver operating characteristic (ROC) analysis for diagnostic performance of the four-autoantibody signature to distinguish individuals with ESCC from matched controls at 6 months to 6 years before clinical diagnosis