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Table 2 Effects of treatment regimens on weight loss, body composition, and metabolic indicesa

From: Effect of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on diabetes remission in adults with obesity and type 2 diabetes: a randomized controlled trial

Variables

Standard treatment group (N = 31)

Intensive treatment group (N = 30)

Difference between Groups (95% CI)

N

Change from baseline (95% CI)

Weight (kg)

60

 − 1.52 (− 6.43 to 3.38)

 − 19.29 (− 24.30 to − 14.30)‡

 − 17.77 (− 22.90 to − 12.64) ‡

BMI (kg/m2)

60

 − 0.52 (− 2.30 to 1.27)

 − 6.86 (− 8.68 to − 5.05)‡

 − 6.35 (− 8.21 to − 4.48) ‡

PBF (%)

60

 − 0.64 (− 3.55 to 2.28)

 − 6.28 (− 9.24 to − 3.32)‡

 − 5.64 (− 8.69 to − 2.60) ‡

VFA (cm2)

60

 − 11.30 (− 33.66 to 11.00)

 − 53.80 (− 76.51 to − 31.12)‡

 − 42.49 (− 65.82 to − 19.15) ‡

SMM (kg)

60

 − 0.07 (− 1.37 to 1.23)

 − 0.48 (− 1.80 to 0.84)

 − 0.41 (− 1.76 to 0.94)

CAP (dB/m)

60

 − 10.60 (− 32.50 to 11.30)

 − 59.10 (− 81.42 to − 31.80)‡

 − 48.55 (− 71.46 to − 25.64) ‡

TC (mmol/L)

60

 − 0.38 (− 1.00 to 0.25)

 − 1.26 (− 1.90 to − 0.60)‡

 − 0.89 (− 1.54 to − 0.24)†

TG (mmol/L)

60

 − 0.37 (− 1.76 to 1.03)

 − 1.08 (− 2.49 to 0.34)

 − 0.71 (− 2.17 to 0.74)

HDL-C (mmol/L)

60

 − 0.02 (− 0.14 to 0.10)

0.15 (0.03 to 0.27)†

0.17 (0.05 to 0.30)†

LDL-C (mmol/L)

60

 − 0.07 (− 0.53 to 0.39)

 − 0.44 (− 0.90 to 0.03)

 − 0.36 (− 0.84 to 0.12)

FPG (mmol/L)

60

 − 1.50 (− 2.72 to − 0.28)†

 − 2.09 (− 3.33 to − 0.85)‡

 − 0.59 (− 1.86 to 0.68)

2hPG (mmol/L)

53

 − 4.41 (− 6.43 to − 2.93)‡

 − 5.57 (− 7.62 to − 3.51)‡

 − 1.16 (− 3.27 to 0.95)

FINS (μU/mL)

60

 − 2.89 (− 10.96 to 5.18)

 − 18.74 (− 26.94 to − 10.53)‡

 − 15.85 (− 24.28 to − 7.41)‡

HbA1c (%)

60

 − 0.71 (− 1.36 to − 0.06)†

 − 1.40 (− 2.04 to − 0.76)‡

 − 0.69 (− 1.36 to − 0.20)†

Urea (mmol/L)

56

0.64 (− 0.02 to 1.30)

0.58 (− 0.09 to 1.25)

0.07 (− 0.75 to 0.62)

Creatinine (μmol/L)

56

 − 0.05 (− 4.17 to 4.08)

1.92 (− 2.27 to 6.12)

1.97 (− 2.34 to 6.28)

UA (μmol/L)

60

 − 61.30 (− 106.50 to − 15.99)†

 − 98.00 (− 144.00 to − 51.99)‡

 − 36.74 (− 84.05 to 10.56)

ALT (IU/L)

60

 − 9.33 (− 28.38 to 9.71)

 − 21.46 (− 40.81 to − 2.10)†

 − 12.12 (− 32.02 to 7.78)

AST (IU/L)

60

 − 2.82 (− 13.79 to 8.16)

 − 9.91 (− 21.07 to 1.24)

 − 7.10 (− 18.57 to 4.37)

  1. Abbreviations CI confidence interval, BMI body mass index, PBF percent of body fat, VFA visceral fat area, SMM skeletal muscle mass, CAP controlled attenuation parameter, TC total cholesterol, TG triglyceride, HDL-C high density lipoprotein cholesterol, LDL-C low density lipoprotein cholesterol, FPG fasting plasma glucose, FINS fasting insulin, HbA1c hemoglobin A1c, UA uric acid, ALT alanine aminotransferase, AST aspartate aminotransferase
  2. aAnalyses were conducted with the use of a mixed-effects model, with randomized treatment as a factor and the use of a multiple imputation method for missing data. Bonferroni method was used for pairwise group comparisons
  3. † and‡ indicated significant difference in the changes of weight loss, body composition, and clinical indices between the two treatment groups
  4. †P < 0.05
  5. ‡P < 0.001