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Fig. 1 | BMC Medicine

Fig. 1

From: Integration of multi-omics data to unveil the molecular landscape and role of piRNAs in early-onset colorectal cancer

Fig. 1

Population features and genomic alterations of EOCRC and LOCRC. A A total of 69 EOCRC and 446 LOCRC patients are enrolled in the TCGA cohort. The study diagram in the TCGA cohort is comprised of a comparison in somatic mutation and CNVs, profiling of transcriptome and DNA methylation, selection of diagnostic or prognostic biomarkers, and clinical variation. B,C Somatic mutations of the top mutated genes among different subtypes in EOCRC (B) and LOCRC (C). Genes are ordered by the total mutation frequencies. D,E The distribution of CNVs features across chromosomes for EOCRC (D) and LOCRC (E). TCGA, The Cancer Genome Atlas; EOCRC, early-onset colorectal cancer; LOCRC, late-onset CRC; CNV, copy number variation

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BMC Medicine

ISSN: 1741-7015

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