Fig. 3

Gene expression and epigenetics difference of EOCRC and LOCRC tumors. A Volcano plot illustrates the differentially expressed genes in LOCRC. Upregulated genes in LOCRC and EOCRC patients are shown in red and blue, respectively. B Gene Ontology enrichment analysis for the differential expression genes. C Volcano plot indicates differentially methylated CpGs between EOCRC and LOCRC. Up-methylated CpGs in LOCRC and EOCRC patients are shown in red and blue, respectively. D Gene Ontology enrichment analysis for the CpG-mapped genes. EOCRC, early-onset colorectal cancer; LOCRC, late-onset CRC