Table 2 sEMD Score definition and high-risk group classification 

Risk feature

sEMD HR (95% CI)

Score value

DH cytogenetics

2.20 (1.16–4.21)

1

EM-E at diagnosis

6.12 (2.69–13.92)

2

 ≥ 3 osteolytic lesions

3.15 (1.45–6.82)

1

Non-ASCT

2.10 (1.14–3.86)

1

IgD subtype

3.48 (1.42–8.53)

1

Total score

No (%)

Group (total score)

No (%)

Median time to sEMD

0

60 (13%)

Low (0–2)

390 (87%)

-

1

166 (37%)

2

164 (37%)

3

46 (10%)

High (3–5)

59 (13%)

36 months

4

8 (2%)

5

5 (1%)