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Table 2 Cox proportional hazards regression model to estimate the risk of AD at the last visit

From: Dissecting the clinical and pathological prognosis of MCI patients who reverted to normal cognition: a longitudinal study

 

Stable NC vs. Stable MCI

MCI Reverters vs. Stable MCI

MCI Reverters vs. Stable NC

N

HR (95%CI)

p

N

HR (95%CI)

p

N

HR (95%CI)

p

Primary analysis

 

571

0.091

 (0.042, 0.198)

< 0.001

385

0.104

(0.033, 0.335)

< 0.001

390

1.522

(0.379, 6.108)

0.533

Subgroup analysis

APOE4 allele carrier

195

0.048

 (0.011, 0.208)

< 0.001

145

0.062

(0.008, 0.456)

0.006

116

1.377

(0.110, 17.196)

0.804

APOE4 allele non-carrier

376

0.129

(0.050, 0.334)

< 0.001

240

0.163

(0.038, 0.698)

0.015

274

1.584

(0.300, 8.355)

0.588

Female

304

0.093

 (0.032, 0.271)

< 0.001

239

0.054

(0.007, 0.395)

0.004

187

0.787

(0.084, 7.390)

0.834

Male

267

0.077

 (0.025, 0.244)

< 0.001

164

0.172

(0.040, 0.748)

0.019

203

3.925

(0.611, 25.222)

0.150

  1. Abbreviations: AD Alzheimer’s diseases, NC Normal cognition, MCI Mild cognitive impairment, HR Hazard ratios, CI Confidence interval, APOE Apolipoprotein E
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BMC Medicine

ISSN: 1741-7015

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