Fig. 2
Normative structural connectome (SC) constrains ALFF abnormalities in GGE-GTCS. A Schematic diagram of structural neighborhood analysis [13]. The collective ALFF abnormality of structural neighbors for a given region (red) was modeled as the average abnormality of its directly structurally connected neighbors (blue). B SC-constrained ALFF abnormalities. Brain rendering shows the associations between ALFF abnormalities and SC. The edge thickness on the brain plot indicates the SC strength, and the node size and color represent the degree of SC constraint on ALFF abnormalities (i.e., the larger and redder, the greater the constraint degree). The scatterplot reveals a significant correlation between regional ALFF abnormality and that of structurally connected neighbors. The boxplots show the observed correlation against surrogate correlations generated from spin tests [41, 42] (“Nullspin,” 10,000 repetitions) and rewired tests [65, 66] (“Nullrewired,” 1000 repetitions). Asterisks denote statistical significance (*P < 0.001, one-tailed). C The spatial correlation at the system levels. The statistically significant correlations are depicted in red (Pspin < 0.05, one-tailed, FDR-corrected). List of intrinsic functional networks: DA, dorsal attention; DM, default mode; FP, frontoparietal; LIM, limbic; SM, somatomotor; VIS, visual; VA, ventral attention. List of laminar differentiation classes: HM, heteromodal; IT, idiotypic; PL, paralimbic; UM, unimodal