Fig. 3
Molecular profiles contributing to structural connectome (SC)-constrained ALFF abnormalities in GGE-GTCS. A A multiple linear regression model was constructed to determine the relationships between regional heterogeneous constraints and molecular profiles. B Heatmap shows Pearson’s correlation coefficients between pairs of molecular profiles. C The scatter plot displays the relationship between observed and fitted SC-constrained ALFF abnormalities. D Dominance analysis was used to evaluate the relative importance of molecular profiles to the fit of the model. Error bars represent 95% bootstrap confidence intervals (10,000 repetitions). Asterisks denote the statistical significance regression coefficient (*Pspin < 0.05, FDR-correction). Gene PC1, first component of 15 disease-related gene expression; Receptor PC1, first component of 19 neurotransmitter receptor densities; E/I ratio, excitatory/inhibitory receptor density ratio; Laminar PC1, first component of laminar thickness covariance