Table 1 Baseline characteristics of the study participants, by cohort
Baseline characteristics | UK Biobank cohort | ESTHER cohort | ||||||
|---|---|---|---|---|---|---|---|---|
Participants (n = 154,892) | Cases (n = 1879) | Non-cases (n = 153,070) | p value | Participants (n = 3242) | Cases (n = 103) | Non-cases (n = 3139) | p value | |
Sex, No. (%) | < 0.001 | < 0.001 | ||||||
Male | 68,952 (44.5) | 1040 (55.3) | 67,912 (44.4) | 1551 (47.8) | 68 (66.0) | 1483 (47.2) | ||
Female | 85,940 (55.5) | 839 (44.7) | 85,101 (55.6) | 1691 (52.2) | 35 (34.0) | 1656 (52.8) | ||
Age at blood collection, in years | < 0.001 | < 0.001 | ||||||
Mean (SD) | 54.5 (7.98) | 59.12 (7.20) | 54.45 (7.97) | 61.5 (6.62) | 63.65 (6.04) | 61.42 (6.63) | ||
BMI (kg/m2) | < 0.001 | 0.024 | ||||||
Mean (SD) | 27.35 (4.82) | 28.04 (4.95) | 27.35 (4.81) | 27.68 (4.27) | 28.63 (4.24) | 27.65 (4.27) | ||
Unknown | 567 | 4 | 563 | 4 | – | 4 | ||
Smoking status, No. (%) | < 0.001 | 0.015 | ||||||
Never | 88,045 (56.8) | 887 (47.2) | 87,158 (57.0) | 1558 (48.1) | 44 (42.7) | 1514 (48.2) | ||
Former | 49,639 (32.1) | 776 (41.3) | 48,863 (31.9) | 1068 (32.9) | 47 (45.6) | 1021 (32.5) | ||
Current | 17,163 (11.1) | 216 (11.5) | 16,947 (11.1) | 556 (17.2) | 11 (10.7) | 545 (17.4) | ||
Unknown | 45 | – | 45 | 60 | 1 | 59 | ||
Alcohol consumption, No. (%) | < 0.001 | 0.313 | ||||||
Abstainer | 48,084 (31.0) | 517 (27.5) | 47,567 (31.1) | 1180 (28.9) | 25 (22.6) | 890 (29.1) | ||
Low | 61,727 (39.9) | 760 (40.4) | 60,967 (39.9) | 2308 (56.5) | 68 (65.3) | 1796 (56.2) | ||
Medium | 26,554 (17.1) | 330 (17.6) | 26,224 (17.1) | 199 (4.8) | 4 (4.0) | 155 (4.9) | ||
High | 18,527 (12.0) | 272 (14.5) | 18,255 (11.9) | 63 (1.5) | 3 (3.2) | 41 (1.5) | ||
Unknown | – | – | – | 260 | 3 | 257 | ||
Follow-up time to CRC diagnosis, in years | – | – | ||||||
Median (range) | – | 6.85 (0–15) | – | – | 7.63 (0–18) | – | ||