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Table 2 Performance of the individual and combined risk prediction panels, by internal and external validation

From: Exploring metabolomics for colorectal cancer risk prediction: evidence from the UK Biobank and ESTHER cohorts

 

Internal validation (UKB testing set, n = 46,467)

External validation (ESTHER cohort, n = 3242)

C-index (95% CI)

Individual panels

 Metabolomics risk panel (MRP)

0.602 (0.577, 0.625)

0.542 (0.481, 0.605)

 Environmental risk panel (ERP)

0.688 (0.664, 0.710)

0.638 (0.587, 0.688)

 Genetic risk panel (GRP)

0.633 (0.608, 0.655)

0.636 (0.578, 0.687)

Combined panels

 MRP + GRP

0.665 (0.641, 0.685)

0.633 (0.576, 0.689)

 MRP + ERP

0.688 (0.665, 0.710)

0.647 (0.596, 0.695)

 GRP + ERP

0.725 (0.703, 0.746)

0.688 (0.638, 0.734)

 MRP + GRP + ERP

0.726 (0.704, 0.746)

0.692 (0.641, 0.738)

  1. Model performance was assessed using the concordance index (C-index), with 95% confidence intervals obtained through bootstrap resampling (1000 iterations). The UKB training set was used to develop the models, which were internally validated in the UKB testing set and externally validated in the ESTHER cohort
  2. CI Confidence interval, UKB UK Biobank
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BMC Medicine

ISSN: 1741-7015

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