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Table 1 Anthropometric, ultrasonographic, and laboratory parameters of the studied groups

From: Unveiling lipoprotein subfractions signature in high-FNPO PCOS: implications for PCOM diagnosis and risk assessment using advanced machine learning models

 

Controls (n = 944)

Low-FNPO (n = 792)

High-FNPO (n = 182)

p value

Anthropometric parameters

Age (year)

31.08 ± 4.41

29.36 ± 3.86#

29.28 ± 3.84#

 < 0.001

BMI (kg/m2)

24.41 ± 4.23

25.21 ± 4.50#

24.43 ± 4.13

 < 0.001

Menarche (year)

13.92 ± 1.46

14.11 ± 1.52#

14.10 ± 1.51

0.026

Ultrasonographic findings

FNPO

7.57 ± 2.64

14.61 ± 2.10#

24.51 ± 4.41#$

 < 0.001

Endocrine parameters

FSH (mIU/mL)

7.30 (7.13, 7.47)

6.13 (6.01, 6.24)#

5.72 (5.50, 5.95)#$

 < 0.001

LH (mIU/mL)

5.15 (4.88, 5.42)

8.49 (8.04, 8.95)#

10.48 (9.68, 11.27)#$

 < 0.001

E2 (pg/mL)

35.45 (25.4, 72.08)

39.05 (29, 57.45)#

41.95 (32.05, 50.15)#

 < 0.001

P (ng/mL)

0.53 (0.38, 0.68)

0.57 (0.42, 0.76)#

0.58 (0.43, 0.85)#

 < 0.001

PRL (ng/mL)

17.54 (16.87, 18.20)

17.36 (16.74, 17.99)

15.04 (13.99, 16.09)#$

 < 0.001

T (ng/dL)

23.76 (23.17, 24.36)

34.82 (33.78, 35.86)#

49.08 (46.05, 52.11)#$

 < 0.001

TSH (μIU/mL)

2.30 (1.68, 3.13)

2.37 (1.70, 3.17)

2.49 (1.64, 3.27)

0.590

AMH (ng/mL)

4.23 (4.03, 4.44)

9.50 (9.11, 9.90)#

15.64 (14.68, 16.60)#$

 < 0.001

DHEAS (μg/dL)

237.18 (231.37, 242.98)

258.38 (251.52, 265.25)#

265.29 (247.55, 283.03)#

 < 0.001

Metabolic parameters

Glucose (mmol/L)

5.26 (5.05, 5.69)

5.40 (5.08, 5.71)

5.39 (5.05, 5.65)

0.450

Insulin (mIU/L)

14.64 (14.07, 15.21)

17.24 (16.20, 18.27)#

20.54 (18.53, 22.54)#$

 < 0.001

HOMA-IR

3.60 (3.44, 3.77)

4.25 (3.97, 4.53)#

5.12 (4.51, 5.72)#$

 < 0.001

TG (mmol/L)

1.41 (1.35, 1.46)

1.49 (1.41, 1.57)

1.81 (1.50, 2.12)#$

0.004

CH (mmol/L)

4.53 (4.48, 4.58)

4.55 (4.49, 4.61)

4.74 (4.60, 4.88)#$

0.021

LDL-C (mmol/L)

2.95 ± 0.69

3.02 ± 0.65

3.21 ± 0.77#$

 < 0.001

HDL-C (mmol/L)

1.24 (1.22, 1.26)

1.23 (1.21, 1.25)

1.20 (1.16, 1.24)

0.120

  1. Normally distributed data was shown as mean ± SD, non-normally data was recorded as median (interquartile range), and transformed non-normally data was shown as mean (95% confidence interval). p values were given by chi-square test, nonparametric test, or one-way ANOVA with the post hoc test
  2. Abbreviations: BMI Body mass index, FNPO Follicle number per ovary, FSH Follicle stimulating hormone, LH Luteinizing hormone, E2 Estrogen, P Progesterone, PRL Prolactin, T Testosterone, TSH Thyroid stimulating hormone, AMH Anti-Müllerian hormone, DHEAS Dehydroepiandrosterone sulfate, HOMA-IR Homeostasis model assessment of insulin resistance, TG Triglycerides, CH Total cholesterol, LDL-C Low-density lipoprotein cholesterol, HDL-C High-density lipoprotein cholesterol
  3. #means the significant difference when compared with controls
  4. $means the significant difference when compared with low-FNPO PCOS cases
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BMC Medicine

ISSN: 1741-7015

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