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  1. The nigrostriatal dopamine (DA) system plays a critical role in regulating the sleep–wake state. The relationship between baseline striatal DA transporter (DAT) specific binding ratios (SBR) and rapid eye move...

    Authors: Junli Ren, Haobo Xie, Yiyun Weng, Yaoying Ge, Ruotong Yao, Zihan Jiang, Jinxiu Zhang, Yusheng Zhu, Xiaotong Fu, Junchao Wang, Zijia Liu, Shishu Zhang, Tingxuan Zhang, Guangyong Chen and Dehao Yang
    Citation: BMC Medicine 2024 22:550
    Content type: Research article Published on:

  2. Vaping prevalence has increased rapidly in England since 2021. This study estimated trends between 2013 and 2024 in vaping among ex-smokers, overall and among those who did not use e-cigarettes to support thei...

    Authors: Sarah E. Jackson, Jamie Brown, Loren Kock and Lion Shahab
    Citation: BMC Medicine 2024 22:503
    Content type: Research Published on:

  4. The rapid spread and increase of chikungunya (CHIKV) and dengue (DENV) cases in Brazilian regions in 2023 has raised concerns about the impact of arboviruses on public health. Epidemiological and genomic surve...

    Authors: Augusto César Parreiras de Jesus, Paula Luize Camargos Fonseca, Hugo José Alves, Diego Menezes Bonfim, João Victor Rodrigues Dutra, Filipe Romero Rebello Moreira, Cristiane Pinheiro Toscano de Brito Mendonça, Jéssica Silqueira Hickson Rios, Joice do Prado Silva, Frederico Scott Varella Malta, Isabela Braga-Paz, João Locke Ferreira de Araújo, Jaqueline Silva de Oliveira, Carolina Senra Alves de Souza, Sandra Elisa Barbosa da Silva, Danielle Costa Capistrano Chaves…
    Citation: BMC Medicine 2024 22:546
    Content type: Research Published on:

  5. In England, the number of takeaway food outlets (‘takeaways’) has been increasing for over two decades. Takeaway management zones around schools are an effective way to restrict the growth of new takeaways but...

    Authors: Nina Trivedy Rogers, Ben Amies-Cull, Jean Adams, Michael Chang, Steven Cummins, Daniel Derbyshire, Suzan Hassan, Matthew Keeble, Bochu Liu, Antonieta Medina-Lara, Bea Savory, John Rahilly, Richard Smith, Claire Thompson, Martin White, Oliver Mytton…
    Citation: BMC Medicine 2024 22:545
    Content type: Research Published on:

  6. Cancer survivors face elevated risks of heart failure (HF) and death, with cardiac dysfunction being a significant concern. Current evaluations often emphasize systolic function while insufficiently addressing...

    Authors: Rongjian Yu, Juze Lin, Tingting Fu, Xuhui Huang, Fei Xu, Caizhi Yang, Yuanfeng Fu, Hongwen Fei and Lizhu Lin
    Citation: BMC Medicine 2024 22:544
    Content type: Research Published on:

  7. Bipolar disorder is a complex polygenic disorder that is characterized by recurrent episodes of depression and mania, the heterogeneity of which is likely complicated by epigenetic modifications that remain to...

    Authors: Shufen Li, Hongyu Ni, Yaping Wang, Xiaohui Wu, Jianqiang Bi, Haiyan Ou, Zhongwei Li, Junjiao Ping, Zhongju Wang, Renhao Chen, Qiong Yang, Meijun Jiang, Liping Cao, Tingyun Jiang, Siqiang Ren and Cunyou Zhao
    Citation: BMC Medicine 2024 22:543
    Content type: Research Published on:

  8. Online food delivery (OFD) platforms offer easy access to an abundance of energy-dense and nutrient-poor takeaway foods and may exacerbate existing unhealthy food environments. Efforts to improve population di...

    Authors: Si Si Jia, Allyson R. Todd, Lana Vanderlee, Penny Farrell, Margaret Allman-Farinelli, Gary Sacks, Alice A. Gibson and Stephanie R. Partridge
    Citation: BMC Medicine 2024 22:542
    Content type: Review Published on:

  9. Front-of-pack (FOP) warning labels have demonstrated effectiveness for reducing sugar-sweetened beverage (SSB) consumption and switching to water. However, an unintended consequence is that they may also incre...

    Authors: Caroline Miller, Enola Kay, Joanne Dono and Kerry Ettridge
    Citation: BMC Medicine 2024 22:541
    Content type: Research Published on:

  10. Clinical management of patients with chronic cardiometabolic disease is complicated by polypharmacy. Consequently, when patients clinically deteriorate, physicians are challenged to distinguish both medication...

    Authors: Randy E. David, Kelsy Gibson Ferrara, Joshua Schrecker, David Paculdo, Steven Johnson, Rhonda Bentley-Lewis, Rebecca Heltsley and John W. Peabody
    Citation: BMC Medicine 2024 22:540
    Content type: Research Published on:

  11. In the contemporary management of heart failure with reduced ejection fraction (HFrEF), the recommended quadruple guideline-directed medical therapy (GDMT) consists of angiotensin receptor-neprilysin inhibitor...

    Authors: Anil Sahin, Ahmet Celik, Dilek Ural, Inci Tugce Colluoglu, Naim Ata, Emine Arzu Kanik, Mustafa Mahir Ulgu, Suayip Birinci and Mehmet Birhan Yilmaz
    Citation: BMC Medicine 2024 22:539
    Content type: Research Published on:

  12. Chronic insomnia increases the risk of various health problems and mental illness. Existing research suggests promise for both transcranial direct current stimulation (tDCS) and repetitive transcranial magneti...

    Authors: Qi Zhou, Zhiwang Liu, Chang Yu, Qiao Wang, Wenhao Zhuang, Yafang Tang, Tianming Zheng, Haihang Yu and Dongsheng Zhou
    Citation: BMC Medicine 2024 22:538
    Content type: Research Published on:

  13. We are now in the fifth year of an ongoing pandemic, and Canada continues to experience significant surges of COVID-19 infections. In addition to the acute impacts of deaths and hospitalizations, there is grow...

    Authors: David Fisman, Jillian Horton, Matthew Oliver, Mark Ungrin, Joseph Vipond, Julia M. Wright and Dick Zoutman
    Citation: BMC Medicine 2024 22:537
    Content type: Debate Published on:

  14. The relationship between serum urea concentration and cancer in patients with metabolic syndrome (MetS) remains unclear. This study aimed to investigate the association between serum urea concentration and 16 ...

    Authors: E Wu, Guo-Fang Wei, Yang Li, Meng-Kai Du and Jun-Tao Ni
    Citation: BMC Medicine 2024 22:536
    Content type: Research Published on:

  15. No specific triglyceride-lowering therapy is recommended in patients with hypertriglyceridemia-associated acute pancreatitis (HTG-AP), primarily because of the lack of quality evidence. This study aimed to des...

    Authors: Jing Zhou, Zuozheng Wang, Qinghong Liu, Longxiang Cao, Enrique de-Madaria, Gabriele Capurso, Christian Stoppe, Dong Wu, Wei Huang, Yingjie Chen, Siyao Liu, Donghuang Hong, Yun Sun, Zhenguo Zeng, Kaixiu Qin, Haibin Ni…
    Citation: BMC Medicine 2024 22:535
    Content type: Research article Published on:

  16. This study explored the influence of type 2 diabetes and impaired glucose tolerance (IGT) on the risk of the multimorbidity cluster of cardiovascular disease (CVD) and cancer.

    Authors: Fei Chen, Jinping Wang, Siyao He, Yifan He, Yali An, Qiuhong Gong, Xiaoping Chen, Ying Shuai, Xuan Wang, Yanyan Chen, Bo Zhang and Guangwei Li
    Citation: BMC Medicine 2024 22:534
    Content type: Research Published on:

  18. Long-COVID symptoms remain incompletely defined due to a large heterogeneity in the populations studied, case definitions, and settings of care. The aim of this study was to assess, in patients accessing care ...

    Authors: Marco Floridia, Marina Giuliano, Liliana Elena Weimer, Maria Rosa Ciardi, Piergiuseppe Agostoni, Paolo Palange, Patrizia Rovere Querini, Silvia Zucco, Matteo Tosato, Aldo Lo Forte, Paolo Bonfanti, Donato Lacedonia, Emanuela Barisione, Stefano Figliozzi, Paola Andreozzi, Cecilia Damiano…
    Citation: BMC Medicine 2024 22:532
    Content type: Research Published on:

  19. Human artificial corneas (HAC) generated by tissue engineering recently demonstrated clinical usefulness in the management of complex corneal diseases. However, the biological mechanisms associated to their re...

    Authors: Olimpia Ortiz-Arrabal, Cristina Blanco-Elices, Carmen González-Gallardo, David Sánchez-Porras, Miguel Etayo-Escanilla, Paula Ávila Fernández, Jesús Chato-Astrain, Óscar-Darío García-García, Ingrid Garzón and Miguel Alaminos
    Citation: BMC Medicine 2024 22:531
    Content type: Research Published on:

  20. Cognitive fusion MRI-guided targeted biopsy (cTB) has been widely used in the diagnosis of prostate cancer (PCa). However, cTB relies heavily on the operator’s experience and confidence in MRI readings. Our ob...

    Authors: Ruiyi Deng, Yi Liu, Kexin Wang, Mingjian Ruan, Derun Li, Jingyun Wu, Jianhui Qiu, Pengsheng Wu, Peidong Tian, Chaojian Yu, Jiaheng Shang, Zihou Zhao, Jingcheng Zhou, Lin Cai, Xiaoying Wang and Kan Gong
    Citation: BMC Medicine 2024 22:530
    Content type: Research Published on:

  21. Intermittent fasting (IF) holds promise for enhancing metabolic health. However, the optimum IF forms and their superiority over continuous energy restriction (CER) remain unclear due to disconnected findings.

    Authors: Yu-En Chen, Hui-Li Tsai, Yu-Kang Tu and Ling-Wei Chen
    Citation: BMC Medicine 2024 22:529
    Content type: Research Published on:

  22. The adverse effects of early-life tobacco smoke exposure on chronic kidney disease (CKD) risk remain unclear. This study aimed to investigate the associations of early-life tobacco smoke exposure with CKD inci...

    Authors: Bingxin Shang, Yuxin Yao, Haoyu Yin, Yujia Xie, Shiyu Yang, Xiaojie You, Haoxiang Liu, Miao Wang and Jixuan Ma
    Citation: BMC Medicine 2024 22:528
    Content type: Research Published on:

  23. The extent to which type 2 diabetes (T2D) reduces life expectancy depends on the risk of complications. We aimed to characterise the relationship between risk factors for diabetes complications and life expect...

    Authors: Dahai Yu, Zhanzheng Zhao, Karen Pickering, John Baker, Richard Cutfield, Brandon J. Orr-Walker, Gerhard Sundborn, Zheng Wang, Yamei Cai, Hang Fu, Chengzeng Wang and David Simmons
    Citation: BMC Medicine 2024 22:527
    Content type: Research Published on:

  24. Previous observational studies have suggested diabetic patients should synchronize their foods and nutrient intake with their biological rhythm; however, the optimal intake time of coffee and tea for reducing ...

    Authors: Ruiming Yang, Qianqian Lei, Zijie Liu, Xinyu Shan, Sijia Han, Yiwei Tang, Fengru Niu, Hui Liu, Wenbo Jiang, Wei Wei and Tianshu Han
    Citation: BMC Medicine 2024 22:526
    Content type: Research Published on:

  27. Authors: Dorota Zarębska-Michaluk, Michał Brzdęk, Olga Tronina, Justyna Janocha-Litwin, Marek Sitko, Anna Piekarska, Jakub Klapaczyński, Anna Parfieniuk-Kowerda, Barbara Sobala-Szczygieł, Magdalena Tudrujek-Zdunek, Łukasz Laurans and Robert Flisiak
    Citation: BMC Medicine 2024 22:524
    Content type: Correction Published on:

    The original article was published in BMC Medicine 2024 22:486

  28. The effect of milk on the risk of ischemic heart disease (IHD) and acute myocardial infarction (MI) is unclear. We aimed to examine the association between non-fermented and fermented milk consumption on these...

    Authors: Karl Michaëlsson, Eva Warensjö Lemming, Susanna C. Larsson, Jonas Höijer, Håkan Melhus, Bodil Svennblad, John A. Baron, Alicja Wolk and Liisa Byberg
    Citation: BMC Medicine 2024 22:483
    Content type: Research Published on:

  29. Zaire Ebolavirus disease (EVD) outbreaks can be controlled using rVSV-ZEBOV vaccination and other public health measures. People in high-risk areas may have pre-existing antibodies from asymptomatic Ebolavirus...

    Authors: Conall H. Watson, Pierre-Stéphane Gsell, Yper Hall, Anton Camacho, Ximena Riveros, Godwin Enwere, Andrea Vicari, Séverine Danmadji Nadlaou, Alhassane Toure, Ismaila M. Sani, Abdourahamane Diallo, Cece Kolie, Sophie Duraffour, Kékoura Ifono, Andre Maomou, Kassie Dore…
    Citation: BMC Medicine 2024 22:523
    Content type: Research Published on:

  30. Postoperative radiotherapy (PORT) is crucial for patients with thoracic locally advanced esophageal squamous cell carcinoma (LA-ESCC, pT3-4aN0-3M0) following esophagectomy. However, the appropriate radiation v...

    Authors: Ya Zeng, Jiancheng Li, Jingjun Ye, Gaohua Han, Wenguang Luo, Chaoyang Wu, Songbing Qin, Wendong Gu, Shengguang Zhao, Yufei Zhao, Bing Xia, Zhengfei Zhu, Xianghui Du, Yuan Liu, Jun Liu, Hongxuan Li…
    Citation: BMC Medicine 2024 22:522
    Content type: Research article Published on:

  31. Hepatitis B virus (HBV) is an enveloped DNA virus that causes chronic hepatitis B (CHB) infection. Annexin, a Ca2+-activated protein, is widely expressed in various organs and tissues and has potential utility in...

    Authors: Luo Yang, Xianzhi Liu, Limin Zhen, Ying Liu, Lina Wu, Wenxiong Xu, Liang Peng and Chan Xie
    Citation: BMC Medicine 2024 22:521
    Content type: Research Published on:

  32. Predicting which children and young people (CYP) are at the highest risk of developing post-COVID-19 condition (PCC) could improve care pathways. We aim to develop and validate prediction models for persistent...

    Authors: Manjula D. Nugawela, Terence Stephenson, Roz Shafran, Trudie Chalder, Emma Dalrymple, Tamsin Ford, Lana Fox-Smith, Anthony Harnden, Isobel Heyman, Shamez N. Ladhani, Kelsey McOwat, Ruth Simmons, Olivia Swann, Elizabeth Whittaker and Snehal M. Pinto Pereira
    Citation: BMC Medicine 2024 22:520
    Content type: Research Published on:

  33. Global food systems are essential to sustain life; however, unhealthy diets are the leading cause of poor health and death worldwide. Natural food environments are a critical source of healthful food such as f...

    Authors: Penny Farrell, Erica Reeve, Ellen Johnson, Anna K. Farmery, Dori Patay, Anne Marie Thow, Jonathan Wu and Jessica R. Bogard
    Citation: BMC Medicine 2024 22:519
    Content type: Research article Published on:

  34. Epidemiological studies show inconsistent links between hearing/vision impairment and dementia risk. Using multisource data, we investigated how single or combined sensory impairments relate to risks of all-ca...

    Authors: Fan Jiang, Qiuyue Dong, Sijia Wu, Xinhui Liu, Alimu Dayimu, Yingying Liu, Hanbing Ji, Le Wang, Tiemei Liu, Na Li, Xiaofei Li, Peipei Fu, Qi Jing, Chengchao Zhou, Hongkai Li, Lei Xu…
    Citation: BMC Medicine 2024 22:518
    Content type: Research Published on:

  35. With over 2 million grafts performed annually, bone ranks second only to blood in the frequency of transplants. This high demand is primarily driven by the persistent challenges posed by bone defects, particul...

    Authors: Markus Laubach, Stephen Whyte, Ho Fai Chan, Tina Frankenbach-Désor, Susanne Mayer-Wagner, Frank Hildebrand, Boris M. Holzapfel, Ulrich Kneser, Uwe Dulleck and Dietmar W. Hutmacher
    Citation: BMC Medicine 2024 22:517
    Content type: Research Published on:

  36. African children with severe malaria are at increased risk of non-typhoidal salmonellae co-infection. Broad-spectrum antibiotics are recommended by guidelines but the optimal class and dose have not been estab...

    Authors: Roisin Connon, Peter Olupot-Olupot, Arthur M. A. Pistorius, William Okiror, Tonny Ssenyondo, Rita Muhindo, Sophie Uyoga, Ayub Mpoya, Thomas N. Williams, Diana M. Gibb, A. Sarah Walker, Rob ter Heine, Elizabeth C. George and Kathryn Maitland
    Citation: BMC Medicine 2024 22:516
    Content type: Research article Published on:

  37. As part of the UK government’s obesity strategy, the Food (Promotion and Placement) (England) Regulations 2021 were implemented in October 2022 to restrict the prominent placement of products high in fat, suga...

    Authors: Preeti Dhuria, Sarah Muir, Sarah Jenner, Emma Roe, Wendy Lawrence, Janis Baird and Christina Vogel
    Citation: BMC Medicine 2024 22:514
    Content type: Research Published on:

  38. Endometriosis, affecting 10% of women in their reproductive years, remains poorly understood. Both individual and environmental unexplained factors are implicated in this heterogenous condition. This study aim...

    Authors: Guillaume Parpex, Benoît Chassaing, Mathilde Bourdon, Pietro Santulli, Ludivine Doridot, Marine Thomas, Frédéric Batteux, Sandrine Chouzenoux, Charles Chapron, Carole Nicco and Louis Marcellin
    Citation: BMC Medicine 2024 22:513
    Content type: Research Published on:

  39. Dietary intake plays a pivotal role in the prevalence and management of obesity. While women and men exhibit differences in dietary habits and food-related behaviors, sex-based weight loss recommendations are ...

    Authors: Michal Rein, Matan Elkan, Anastasia Godneva, Noa Cohen Dolev and Eran Segal
    Citation: BMC Medicine 2024 22:512
    Content type: Research article Published on:

  40. Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown cause. N6-methyladenosine (m6A) is the most common mRNA modification and participates in various immune processes such as interferon produ...

    Authors: Yu Liu, Xiaohua Wang, Mingcheng Huang, Ailing Luo, Shanshan Liu, Mansi Cai, Weinian Li, Shiwen Yuan, Zhihua Zheng, Xiaoping Liu and Chun Tang
    Citation: BMC Medicine 2024 22:511
    Content type: Research Published on:

  41. Numerous studies have investigated links between body mass index (BMI) trajectories and cardiovascular risk, yet discrepancies in BMI measurement duration and timing of the cardiovascular-related outcome evalu...

    Authors: Gang Wang, Dang Wei, Simon Kebede Merid, Sandra Ekström, Susanna Klevebro, Natalia Hernandez-Pacheco, Sophia Björkander, Petter Ljungman, Inger Kull, Jochen M. Schwenk, Anna Bergström and Erik Melén
    Citation: BMC Medicine 2024 22:510
    Content type: Research Published on:

  42. Identifying children and adolescents with cardiometabolic risk at an early stage is crucial for effective treatment and prevention. From a practical perspective, this could be accomplished by assessing the pre...

    Authors: Helmut Schröder, Charlotte Juton, Michael I. Goran, Julia Wärnberg, Maddi Osés, Marcela Gonzalez-Gross, Narcis Gusi, Susana Aznar, Elena Marín-Cascales, Miguel González-Valeiro, Estefanía Herrera-Ramos, Nicolás Terrados, Josep A. Tur, Marta Segú, Montserrat Fitó, Lourdes Ribas-Barba…
    Citation: BMC Medicine 2024 22:509
    Content type: Research Published on:

  43. Endometriosis is a chronic, estrogen-dependent, benign condition, affecting 10–15% of women of reproductive age. It is associated with a prevalence of sexual dysfunction that is nearly twice as high as that se...

    Authors: Alexandra Perricos, Manuela Gstoettner, Sahra Iklil, Florian Heinzl, Lejla Sandrieser, Jana Heine, Heinrich Husslein, Lorenz Kuessel, Christine Bekos and René Wenzl
    Citation: BMC Medicine 2024 22:508
    Content type: Research Published on:

  45. External causes of death, such as accidents, substance use, and suicide, contribute substantially to mortality during adolescence and early adulthood and show marked sex differences. Individuals born preterm a...

    Authors: Josephine Funck Bilsteen, Signe Opdahl, Anna Pulakka, Per Ivar Finseth, Weiyao Yin, Kristine Pape, Jorun Schei, Johanna Metsälä, Anne-Marie Nybo Andersen, Sven Sandin, Eero Kajantie and Kari Risnes
    Citation: BMC Medicine 2024 22:506
    Content type: Research article Published on:

  46. Antenatal corticosteroids are recommended for women at risk of preterm birth from 24 to 34 weeks’ gestation as they reduce neonatal morbidity and mortality, but evidence regarding their long-term effects on of...

    Authors: Anthony G. B. Walters, Greg D. Gamble, Caroline A. Crowther, Stuart R. Dalziel, Carl L. Eagleton, Christopher J. D. McKinlay, Barry J. Milne and Jane E. Harding
    Citation: BMC Medicine 2024 22:505
    Content type: Research Published on:

  47. Abnormal sensory perception, particularly pain insensitivity (PAI), is a typical symptom of autism spectrum disorder (ASD). Despite the role of myelin metabolism in the regulation of pain perception, the mecha...

    Authors: Lili Fan, Qi Li, Yaxin Shi, Xiang Li, Yutong Liu, Jiaqi Chen, Yaqi Sun, Anjie Chen, Yuan Yang, Xirui Zhang, Jia Wang and Lijie Wu
    Citation: BMC Medicine 2024 22:504
    Content type: Research Published on:

  48. Transmembrane 9 superfamily member 1 (TM9SF1) is involved in inflammation. Since both inflammatory and autoimmune diseases are linked to immune cells regulation, this study investigated the association between...

    Authors: Juan Xiao, Zhenwang Zhao, Fengqiao Zhou, Jinsong Xiong, Zean Yang, Baoxian Gong, Lei Xiang, Mingming Liu, Fengsheng Cao, Hong Xiao, Huabo Chen, Anbing Zhang and Ke Wang
    Citation: BMC Medicine 2024 22:502
    Content type: Research Published on:

  49. We aimed to develop risk tools for dementia, stroke, myocardial infarction (MI), and diabetes, for adults aged ≥ 65 years using shared risk factors.

    Authors: Md Hamidul Huque, Scherazad Kootar, Kim M. Kiely, Craig S. Anderson, Martin van Boxtel, Henry Brodaty, Perminder S. Sachdev, Michelle Carlson, Annette L. Fitzpatrick, Rachel A. Whitmer, Miia Kivipelto, Louisa Jorm, Sebastian Köhler, Nicola T. Lautenschlager, Oscar L. Lopez, Jonathan E. Shaw…
    Citation: BMC Medicine 2024 22:501
    Content type: Research Published on:

  50. This study aimed to characterise patterns of tobacco smoking and vaping among older adults (≥ 65 years) in England, to explore harm perceptions of e-cigarettes among those who smoke, and to estimate the real-w...

    Authors: Sarah E. Jackson, Jamie Brown, Lion Shahab and Sharon Cox
    Citation: BMC Medicine 2024 22:500
    Content type: Research Published on:
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